- Chronic hepatitis B virus (HBV) infection in adults with compensated liver disease:
- PO 25mg OD
- PO 25mg OD
- Perinatal transmission Hepatitis B infection prophylaxis (Off-label):
- PO 25mg OD
- Initially at 28-32 week gestation
- For pregnant patients with HBV DNA >200,000
- 1st-line agent
Tablet: 25mg
- To be given with meals
Nucleotide Reverse Transcriptase Inhibitor (NRTI)
It inhibits reverse transcriptase and incorporates into viral DNA, resulting in DNA chain termination
- Headache
- Elevated ALT/AST
- Abdominal pain
- Fatigue
- Cough
- Nausea
- Back pain
- Arthralgia
- Diarrhea
- Dyspepsia
- Glycosuria
- Hypercholesterolemia
- Elevated CK
- Hyperamylasemia
- Bone density loss
- Vomiting
- Rash
- Flatulence
- Weight gain
- Concurrent HBV infection and untreated HIV infection
WARNING
Severe acute exacerbations of hepatitis may occur in HBV-infected patients when tenofovir is discontinued
- Carbamazepine
- Cidofovir
- Phenobarbital
- Phenytoin
- Rifampin
Drug Status
| Availability | Prescription or OTC by Pharmacist |
| Pregnancy | Weigh risk vs benefit |
| Breastfeeding | Weigh risk vs benefit but avoid breastfeeding if nipples cracked or bleeding |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Vemlidy | 25mg | Tablet | 30’s | Gilead Sciences | Phillips Therapeutics |