- Tuberculosis:
- PO 10mg/kg/day OR 10mg/kg twice weekly
- Max 600mg/dose
- May be given with isoniazid or with isoniazid and pyrazinamide
- Meningococcal prophylaxis for asymptomatic meningococcal carriers:
- PO 600mg BD *2/7
- Prophylaxis of contacts of patients with Haemophilus influenzae type B infection:
- PO 600mg/day *4/7
- Staphylococcal prosthetic valve endocarditis (Off-label):
- PO 300mg TDS for at least 6 weeks
- Give with gentamicin gram positive synergy *2/52 and nafcillin, cefazolin or vancomycin
- Paucibacillary leprosy (Off-label):
- PO 600mg monthly *6/12
- May continue treatment beyond 6 months in refractory cases
- Part of multi-drug regimen
- Multibacillary leprosy (Off-label):
- PO 600mg monthly *12/12
- May continue treatment beyond 12 months in refractory cases
- Part of multi-drug regimen
- Brucellosis (Off-label):
- PO 600mg OD *6/12
- Part of multi-drug regimen
Capsule: 300mg
To be taken on an empty stomach
Rifamycin antitubercular
It inhibits DNA-dependent RNA polymerase
- Red-orange body fluid discoloration
- Red-orange tooth discoloration
- Anorexia
- Nausea
- Vomiting
- Headache
- Elevated ALT/AST
- Fatigue
- Drowsiness
- Dizziness
- Abdominal pain
- Diarrhea
- Hypersensitivity reaction
- Influenza-like symptoms
- Dyspnea
- Ataxia
- Vision changes
- Contact lens staining
- Hypersensitivity to components
- Artemether/lumefantrine
- Atazanavir
- Bictegravir
- Cabotegravir
- Cariprazine
- Cobicistat
- Cobimetinib
- Darunavir
- Doravirine
- Elbasvir/grazoprevir
- Elvitegravir/cobicistat/emtricitabine/tenofovir
- Etravirine
- Fosamprenavir
- Fostemsavir
- Glecaprevir/pibrentasvir
- Irinotecan
- Irinotecan liposomal
- Isavuconazonium sulfate
- Ledipasvir/sofosbuvir
- Lonafarnib
- Lorlatinib
- Lumacaftor/ivacaftor
- Lumefantrine
- Lurasidone
- Mavacamten
- Naloxegol
- Nelfinavir
- Nirmatrelvir
- Nirmatrelvir/ritonavir
- Ombitasvir/paritaprevir/ritonavir & dasabuvir (dsc)
- Panobinostat
- Pirfenidone
- Praziquantel
- Regorafenib
- Rilpivirine
- Roflumilast
- Saquinavir
- Tipranavir
- Vandetanib
- Velpatasvir
- Voriconazole
Drug Status
| Availability | Prescription only |
| Pregnancy | Weigh risk vs benefit |
| Breastfeeding | Weigh risk vs benefit |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Rifacos | 150mg | Capsule | 100’s | Cosmos Ltd | Cosmos Ltd |
| Rifacos | 300mg | Capsule | 100’s | Cosmos Ltd | Cosmos Ltd |
| Unirif | 150mg | Capsule | 100’s | Universal Corporation | Universal Corporation |
| Unirif | 300mg | Capsule | 100’s | Universal Corporation | Universal Corporation |