• Tuberculosis (pulmonary and extrapulmonary)
  • Continuation phase of TB treatment (after 2 months of RHZE or RHE)
  • May be used in latent TB infection (LTBI) prophylaxis in some regimens

Dosage (based on weight):

  • 30–37 kg:2 tablet
  • 38–54 kg:3 tablets
  • 55–70 kg:4 tablets
  • >70 kg:5 tablets
  • Administered once daily, usually for 4 months in continuation phase
  • Take on an empty stomach
  • Rifampicin: 150 mg
  • Isoniazid: 75 mg
     (Also available in 300 mg Rifampicin + 150 mg Isoniazid combinations)
  • Take on an empty stomach, preferably 30–60 minutes before food
  • Avoid antacids close to the dose
  • Vitamin B6 (pyridoxine) supplementation is recommended to prevent neuropathy
  • Rifampicin: Inhibits DNA-dependent RNA polymerase, bactericidal
  • Isoniazid: Inhibits mycolic acid synthesis, essential for mycobacterial cell walls, bactericidal against actively growing bacilli
  • Nausea, anorexia, fatigue
  • Red/orange discoloration of body fluids (rifampicin)
  • Peripheral neuropathy (isoniazid)
  • Active liver disease
  • Severe hepatic impairment
  • Known hypersensitivity to rifampicin or isoniazid
  • Rifampicin is a strong enzyme inducer:
    • ↓ efficacy of oral contraceptives, warfarin, antiretrovirals
  • Isoniazid may increase levels of phenytoin, carbamazepine
  • Avoid alcohol → ↑ hepatotoxic risk

                                   Drug Status

Availability
Pregnancy
Breastfeeding
Schedule
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
AkuriT 150mg/75mg Tablet 90’s Lupin Limited Nairobi Enterprises