- Active tuberculosis in HIV negative patients:
- PO 15-30mg/kg OD OR 50mg/kg twice weekly
- Max 2g/day
- Part of multi-drug regimen
- Active tuberculosis in HIV exposed/infected patients:
- PO 20-40mg/kg/dose OD
- Max 2g/day
- Part of multi-drug regimen
Tablet: 500mg
Taken without regards to meals
Antitubercular agent
The exact mechanism of action unknown but is thought to lower intracellular pH, inhibiting mycobacterial growth
- Anorexia
- Rash
- Urticaria
- Nausea
- Vomiting
- Malaise
- Arthralgia
- Photosensitivity
- Hyperuricemia
- Gout
- Elevated LFTs
- Severe hepatic damage
- Acute gout
- Hypersensitivity to components
None restricted
Drug Status
| Availability | Prescription only |
| Pregnancy | Category C |
| Breastfeeding | Weigh risk vs benefit |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| PZA | 500mg | Tablet | 100’s | Cosmos Ltd | Cosmos Ltd |