- HIV infection as pharmacokinetic enhancer of other PIs:
- In combination with other antiretroviral agents:
- Initially PO 300mg BD increased by 100mg BD to 600mg BD over 5 days as tolerated
- Initially PO 300mg BD increased by 100mg BD to 600mg BD over 5 days as tolerated
- In combination with other antiretroviral agents:
-
- Use as booster with another protease inhibitor:
- PO 100-400mg OD/BD
- Use as booster with another protease inhibitor:
-
- Age ≥1 month:
- Initially PO 250mg/m² BD then increase by 50mg/m² every 2-3days to 350-400mg/m² BD
- Max: 600mg BD
- Age ≥1 month:
-
- Adolescents:
- Initially PO 300mg BD then increase by 100mg BD to 600mg BD over 5 days as tolerated
- Adolescents:
Tablet: 100mg
- Taken with food
- Gradually increase dose to avoid nausea/vomiting
Protease inhibitor antiretroviral
It binds to active site of HIV protease, preventing mature virus particle formation
- Diarrhea
- Nausea
- Paresthesia
- Hypercholesterolemia
- Vomiting
- Fatigue
- Rash
- Abdominal pain
- Hypertriglyceridemia
- Cough
- Dysgeusia
- Oropharyngeal pain
- Dizziness
- Asthenia
- Flushing
- GGT elevated
- Pruritus
- Dyspepsia
- Elevated CK
- Myalgia
- Hypersensitivity reaction
- Elevated ALT/AST
- Flatulence
- Hyperamylasemia (peds patients)
- Blurred vision
- Edema
- Thrombocytopenia (peds patients)
- Acne
- Hyperuricemia
- Confusion
- Attention disturbance
- Lipodystrophy
- Hypersensitivity to components
- Breastfeeding
WARNING
Potential serious and/or life-threatening adverse effects in combination with certain sedative hypnotics, antiarrhythmics or ergot alkaloids due to inhibited drug metabolism by ritonavir
- Alfuzosin
- Amiodarone
- Apalutamide
- Atorvastatin
- Bosentan
- Butabarbital
- Butalbital
- Carbamazepine
- Cenobamate
- Cisapride
- Clozapine
- Colchicine
- Conivaptan
- Dabrafenib
- Dihydroergotamine
- Disulfiram
- Dronedarone
- Efavirenz
- Elagolix
- Eletriptan
- Eliglustat
- Enzalutamide
- Eplerenone
- Ergotamine
- Estetrol (contraceptive)
- Ethinyl estradiol (contraceptive)
- Ethinyl estradiol (hormone replacement)
- Everolimus
- Finerenone
- Flecainide
- Flibanserin
- Fosphenytoin
- Grazoprevir
- Isavuconazonium
- Ivabradine
- Lomitapide
- Lonafarnib
- Lorlatinib
- Lovastatin
- Lumacaftor/ivacaftor
- Lurasidone
- Mavacamten
- Methylergonovine
- Metronidazole
- Midazolam
- Mitapivat
- Mitotane
- Modafinil
- Nafcillin
- Naloxegol
- Pacritinib
- Pentobarbital
- Pexidartinib
- Phenobarbital
- Phenytoin
- Pimozide
- Primidone
- Propafenone
- Quinidine (antiarrhythmic)
- Ranolazine
- Rifabutin
- Rifampin
- Rifapentine
- Sildenafil
- Silodosin
- Simvastatin
- Sirolimus
- Sotorasib
- Tacrolimus
- Thioridazine
- Tinidazole
- Tolvaptan
- Triazolam
- Ubrogepant
- Venetoclax
- Voclosporin
- Voriconazole
Drug Status
| Availability | Prescription only |
| Pregnancy | Avoid oral solution due to alcohol content |
| Breastfeeding | Not indicated |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Norvir | 100mg | Tablet | 60’s | Abbvie | Phillips Therapeutics |