• HIV 1 infection in combination with other antiretroviral agents for HIV-1 infection:
    • Adults: PO 400mg BD
    • ≥4 weeks children:
      • 11 to <14 kg: PO 75mg BD (3 x 25mg tablets)
      • 14 to <20 kg: PO 100mg BD (1 x 100mg tablet)
      • 20 to <28 kg: PO 150mg BD (1.5 x 100mg tablets)
      • 28 to <40 kg: PO 200mg BD (2 x 100mg tablet)
      • ≥40 kg: PO 300mg BD (3 x 100mg tablets)
  • Tablet:
    • 400mg
  • Taken without regard to food
  • The 25mg chewable tablet may be crushed and mixed in a cup with a teaspoon of liquid such as water, juice or breast milk.

Intergrase inhibitor antiretroviral

It inhibits HIV integrase, preventing viral DNA insertion into host cell DNA

  • Insomnia
  • Headache
  • Dizziness
  • Nausea
  • Asthenia
  • Fatigue
  • Hyperbilirubinemia
  • Elevated CK
  • Weight gain
  • Hypersensitivity to class/components
  • Breastfeeding
  • Aluminum hydroxide
  • Aluminum hydroxide/magnesium carbonate
  • Aluminum hydroxide/magnesium trisilicate
  • Elvitegravir/cobicistat/emtricitabine/tenofovir
  • Magnesium supplement

                          Drug Status

Availability Prescription only
Pregnancy Use with caution
Breastfeeding Contraindicated
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Isentress 400mg Tablet 60’s MSD Imperial Managed