- HIV infection:
- 1 tab OD
- 1 tab OD
- HIV pre-exposure prophylaxis (PrEP):
- 1 tab OD
- 1 tab OD
- Treatment of hepatitis B/HIV-1 co-infection (Off-label):
- 1 tab OD
- Part of multi-drug regimen
- HIV post-exposure prophylaxis (PEP) (Off-label):
- 1 tab OD
- Part of multi-drug regimen
Tablet: 300mg/200mg
For pre-exposure prophylaxis, check HIV status before treatment start and every 3 months or upon diagnosis of other sexually transmitted infections
Emtricitabine: Nucleoside reverse transcriptase inhibitor (NRTI). Following phosphorylation, it interferes with HIV viral DNA polymerase and inhibits viral replication
Tenofovir: Nucleoside reverse transcriptase inhibitor (NRTI); Following hydrolysis and phosphorylation, it inhibits HIV-1 reverse transcriptase by competing with AMP as substrate
- Diarrhea
- Nausea & vomiting
- Fatigue
- Headache
- Dizziness
- Depression
- Insomnia
- Abnormal dreams
- Rash
- Hypercholesterolemia
- Elevated Ck
- Bone density loss
- Hyperamylasemia
- Anemia (peds patients)
- URI
- Anxiety
- Arthralgia
- Myalgia
- Cough
- Dyspepsia
- Fever
- Abdominal pain
- Back pain
- Paresthesia
- Peripheral neuropathy
- Pneumonia
- Palmar-plantar hyperpigmentation
- Hypertriglyceridemia
- Elevated LFTs
- Neutropenia
- Hematuria
- Hyperglycemia
- Glycosuria
- Hypersensitivity of class/components
- Use as monotherapy in HIV-infected patients
- Positive or unknown HBsAg status in HIV pre-exposure prophylaxis use
- Positive or unknown HIV status in HIV pre-exposure prophylaxis use
- CrCl <60 (HIV prophylaxis use)
- Concurrent or recent nephrotoxic agent use
WARNING:
- Severe acute HBV exacerbations in HBV/HIV co-infected patients when discontinuing emtricitabine or tenofovir
- Drug-resistant HIV-1 variants have been identified with use of emtricitabine/tenofovir for a PrEP indication following undetected acute HIV infection
- Lamivudine
- Cidofovir
Drug Status
Availability | Prescription only |
Pregnancy | Category B |
Breastfeeding | Contraindication |
Schedule | Not controlled |
BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
---|---|---|---|---|---|
Tavin EM | 300mg/200mg | Tablet | 30’s | Emcure Pharma | Lazor Pharma |
Tenofovir/Emtricitabine | 300mg/200mg | Tablet | 30’s | Mylan Labs C/O Surgilinks Ltd | Surgilinks Ltd |
Truvada | 300mg/200mg | Tablet | 30’s | Gilead Sciences | Phillips Therapeutics |