• HIV infection:
    • 1 tab OD at bedtime
    • >50kg in co-administration with rifampicin: additional 200mg efavirenz required

Tablet: 600mg/200mg/300mg

Take only with water on empty stomach, preferably at bedtime

Emtricitabine: Nucleoside Reverse Transcriptase Inhibitor (NRTI). Following phosphorylation, it interferes with HIV viral DNA polymerase and inhibits viral replication; cytosine analogue

Tenofovir: Nucleoside Reverse Transcriptase Inhibitor (NRTI). Following hydrolysis and phosphorylation, it inhibits HIV-1 reverse transcriptase by competing with AMP as a substrate

Efavirenz: Non-nucleoside reverse transcriptase inhibitor (NNRTI). It binds to reverse transcriptase and blocks DNA polymerase activity and requires no phosphorylation for activity

  • Rash
  • Anxiety
  • Nervousness
  • Depression
  • Drowsiness
  • Dizziness
  • Fatigue
  • Impaired concentration
  • Headache
  • Insomnia
  • Abnormal dreams
  • Hyperlipidemia
  • Elevated ALT/AST
  • Hyperamylasemia
  • Nausea & vomiting
  • Abdominal pain
  • Dyspepsia
  • Anorexia
  • Diarrhea
  • Rhinitis
  • Cough
  • Asthenia
  • Paresthesia
  • Myalgia
  • Arthralgia
  • Elevated CK
  • Hyperglycemia
  • Glycosuria
  • Palmar-plantar hyperpigmentation
  • Lipodystrophy
  • Bone density loss
  • Pruritus
  • Anemia (peds patients)
  • Hematuria
  • Peripheral neuropathy
  • Hypersensitivity to class/components
  • Concurrent or recent nephrotoxic agent use
  • Breastfeeding

WARNING:

Severe acute Hepatitis B exacerbations in HBV/HIV co-infected patients when emtricitabine or tenofovir discontinued

  • Cidofovir
  • Dasabuvir
  • Elbasvir
  • Grazoprevir
  • Lonafarnib
  • Mavacamten
  • Paritaprevir
  • Pimozide
  • Ranolazine
  • Ritonavir
  • Thioridazine
  • Voriconazole

                          Drug Status

Availability Prescription only
Pregnancy Category D
Breastfeeding Contraindicated
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Atripla 600mg/200mg/300mg Tablet 30’s MSD Ltd Imperial Managed
Efavirenz/Emitricitabine/Tenofovir 600mg/200mg/300mg Tablet 30’s Aurobindo Pharma Simba Pharma
Efavirenz/Emtricitabine/Tenofovir 600mg/200mg/300mg Tablet 30’s Strides Pharma Science Universal Corporation
Trustiva 600mg/200mg/300mg Tablet 30’s Hetero Labs Unisel Ltd
Viraday 600mg/200mg/300mg Tablet 30’s Cipla Ltd Phillips Therapeutics