- HIV infection in combination with other anti-retroviral drugs:
- Adults and children >25kg: 1 tab OD
Tablet: 600mg/300mg
- Taken without regards to meals
Abacavir: NRTI (guanosine analog). It inhibits HIV reverse transcriptase by inhibiting viral replication
Lamivudine: NRTI (cytosine analog). It inhibits HIV reverse transcriptase by viral DNA chain termination.
- Hypersensitivity reaction
- Insomnia
- Depression
- Headache
- Fatigue
- Malaise
- Dizziness
- Nausea
- Diarrhea
- Rash
- Fever
- Abdominal pain
- Abnormal dreams
- Anxiety
- Hyperamylasemia
- Elevated ALT/AST
- Patients who have the HLA-B*5701 allele
- Prior hypersensitivity to abacavir or lamivudine
- Moderate or severe hepatic impairment
WARNING
- Severe and sometimes fatal hypersensitivity reaction, with multiple organ involvement, has been observed
- Severe acute HBV exacerbations in HBV/HIV co-infected patients upon lamivudine discontinuation
- Elvitegravir/cobicistat/emtricitabine/tenofovir DF
Drug Status
| Availability | Prescription only |
| Pregnancy | Weigh risk vs benefit |
| Breastfeeding | Contraindicated |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Abacavir/Lamivudine | 600mg/300mg | Tablet | 30’s | Hetero Labs | Unisel Ltd |
| Abacavir/Lamivudine | 600mg/300mg | Tablet | 30’s | Aurobindo Pharma | Simba Pharma |
| Abacavir/Lamivudine | 600mg/300mg | Tablet | 30’s | Mylan Labs C/O Surgilinks Ltd | Surgilinks Ltd |
| Abacavir/Lamivudine | 600mg/300mg | Tablet | 30’s | Aurobindo Pharma | Simba Pharma |
| Kivexa | 600mg/300mg | Tablet | 30’s | GSK Ltd | GSK Ltd |