- Alcohol-related liver disease (acute/chronic)
- Fatty liver disease (NAFLD/NASH)
- Alcohol intoxication (acute)
- Cognitive dysfunction related to chronic alcoholism
- ADHD (under investigation, off-label use)
Dose:
- Acute alcohol intoxication:
- IV: 900–1500 mg single dose
- Chronic liver disease:
- Oral: 500 mg 2–3 times daily (duration varies)
Dosage may vary depending on clinical protocol and country-specific guidelines.
- PO: 500 mg
- IV vials: 300 mg/5 mL or 500 mg/5 mL
- Oral: Take with or without food
- IV: Administered in hospital setting under medical supervision
- Metadoxine = Pyridoxine (Vitamin B6) + Pyrrolidone carboxylate
- Accelerates ethanol metabolism, reduces liver fat accumulation, and supports glutathione synthesis
- Improves hepatic microcirculation, antioxidant activity, and reduces oxidative stress
- Nausea, GI upset
- Headache
- Skin rash (rare)
- Drowsiness or dizziness (rare)
- Hypersensitivity to metadoxine or its components
- Severe kidney impairment (use with caution)
- No major drug interactions reported
- May theoretically interact with CNS depressants (e.g., alcohol, sedatives) when used in high doses
Drug Status
Availability | |
Pregnancy | |
Breastfeeding | |
Schedule |
BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
---|---|---|---|---|---|
Alcomet | 500mg | Tablet | 30’s | Axon Drugs | Axon Drugs |