• Alcohol-related liver disease (acute/chronic)
  • Fatty liver disease (NAFLD/NASH)
  • Alcohol intoxication (acute)
  • Cognitive dysfunction related to chronic alcoholism
  • ADHD (under investigation, off-label use)

Dose:

  • Acute alcohol intoxication:
    • IV: 900–1500 mg single dose
  • Chronic liver disease:
    • Oral: 500 mg 2–3 times daily (duration varies)

Dosage may vary depending on clinical protocol and country-specific guidelines.

  • PO: 500 mg
  • IV vials: 300 mg/5 mL or 500 mg/5 mL
  • Oral: Take with or without food
  • IV: Administered in hospital setting under medical supervision
  • Metadoxine = Pyridoxine (Vitamin B6) + Pyrrolidone carboxylate
  • Accelerates ethanol metabolism, reduces liver fat accumulation, and supports glutathione synthesis
  • Improves hepatic microcirculation, antioxidant activity, and reduces oxidative stress
  • Nausea, GI upset
  • Headache
  • Skin rash (rare)
  • Drowsiness or dizziness (rare)
  • Hypersensitivity to metadoxine or its components
  • Severe kidney impairment (use with caution)
  • No major drug interactions reported
  • May theoretically interact with CNS depressants (e.g., alcohol, sedatives) when used in high doses

                                   Drug Status

Availability
Pregnancy
Breastfeeding
Schedule
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Alcomet 500mg Tablet 30’s Axon Drugs Axon Drugs