- Refractory anaplastic astrocytoma:
- Initially PO 150mg/m2/dose OD on days 1-5 of 28-day cycle for cycle 1
- Maintenance: PO 200mg/m2/dose OD on days 1-5 of 28-day cycle starting cycle 2 if ANC >1500 mm³ and platelets >100,000 mm³
- Newly diagnosed glioblastoma multiforme:
- Concomitant with focal radiotherapy : Initially PO 75mg/m² OD *42/7 days
- PCP prophylaxis required
- Concomitant with focal radiotherapy : Initially PO 75mg/m² OD *42/7 days
-
- Maintenance: Initially PO 150mg/m2/dose OD on days 1-5 of 28-day cycle for cycle 1 then PO 200mg/m2/dose OD on days 1-5 of 28-day cycle starting cycle 2
- Starting 4 weeks after completing concomitant focal radiotherapy phase
- Give for 6 cycles
- Maintenance: Initially PO 150mg/m2/dose OD on days 1-5 of 28-day cycle for cycle 1 then PO 200mg/m2/dose OD on days 1-5 of 28-day cycle starting cycle 2
- Malignant melanoma (Off-label):
- Monotherapy: PO 150-200mg/m2/dose OD on days 1-5 of 28-day cycle
- Combination therapy: PO 150mg/ m2/dose OD on days 1-4 of 21-day cycle
- Capsule:
- 5mg
- 20mg
- 100mg
- 140mg
- 180mg
- 250mg
- To be taken on an empty stomach
- Take capsule consistently either with or without food
- Consider taking antiemetics prior
Alkylating agent antineoplastic
Imidazotetrazine derivative prodrug; it’s active metabolite MTIC methylates guanine-rich areas of DNA that initiate transcription, which lead to DNA double strand breaks and apoptosis
- Alopecia
- Fatigue
- Nausea
- Vomiting
- Headache
- Constipation
- Anorexia
- Seizures
- Rash
- Hemiparesis
- Diarrhea
- Asthenia
- Fever
- Dizziness
- Impaired coordination
- Viral infection
- Amnesia
- Insomnia
- Peripheral edema
- Abdominal pain
- Blurred vision
- Thrombocytopenia
- Pruritus
- Arthralgia
- Myalgia
- Hypersensitivity to class/components
- Hypersensitivity to dacarbazine
- Pregnancy 1st trimester
- ANC <1500
- Plt <100,000
- Live vaccines
- Tamoligene
Drug Status
| Availability | Prescription only |
| Pregnancy | Category D |
| Breastfeeding | Contraindicated |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Column 1 Value | Column 2 Value | Column 3 Value | Column 4 Value | Column 5 Value | Column 6 Value |