• Relapsed or refractory multiple myeloma:
    • PO 4mg *1 on days 1, 8, 15 of 28-day cycle
  • Capsule:
    • 2.3mg
    • 3mg
    • 4mg
  • Should be taken at the same time each day on an empty stomach, at least 1 hour before or 2 hours after a meal
  • If you vomit shortly after taking ixazomib, do not take another dose. Wait until your next scheduled dose time to take the medicine again
  • If the capsule contents get on your skin or eyes, wash your skin with soap and water or rinse your eyes with water
  • Delayed or missed dose: Take dose only if next scheduled dose is ≥72 hours away. Do not double dose to make up for missed dose

Protease inhibitors anticancer

It preferentially binds and inhibits the chymotrypsin-like activity of the beta 5 subunit of the 20S proteasome disrupting cellular homeostasis and causing cell death

  • Thrombocytopenia
  • Neutropenia
  • Diarrhea
  • Constipation
  • Peripheral neuropathy
  • Nausea
  • Peripheral edema
  • Rash
  • Back pain
  • URI
  • Vomiting
  • Cataracts
  • Conjunctivitis
  • Blurred vision
  • Dry eyes
  • Herpes zoster (shingles) reactivation
  • Hypersensitivity
  • Avoid breastfeeding during treatment and for 90 days after discontinuing
  • Not to be taken at the same time with dexamethasone

                          Drug Status

Availability Prescription only
Pregnancy Category X
Breastfeeding Contraindicated
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Ninlaro 2.3mg Capsule 3’s Takeda Pharma Phillips Therapeutics
Ninlaro 3mg Capsule 3’s Takeda Pharma Phillips Therapeutics
Ninlaro 4mg Capsule 3’s Takeda Pharma Phillips Therapeutics