- Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML):
- Chronic phase (newly diagnosed):
- PO 400mg OD, increased to 600mg if tolerable
- PO 400mg OD, increased to 600mg if tolerable
- Chronic phase (newly diagnosed):
-
- Chronic phase after failure of interferon-alpha therapy:
- PO 400mg OD, increased if necessary up to 800mg daily in 2 divided doses
- PO 400mg OD, increased if necessary up to 800mg daily in 2 divided doses
- Chronic phase after failure of interferon-alpha therapy:
-
- Accelerated phase or blast phase:
- PO 600mg OD, may increase to 400mg
- PO 600mg OD, may increase to 400mg
- Accelerated phase or blast phase:
- Relapsed or refractory Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL):
- PO 600mg OD
- PO 600mg OD
- Myelodysplastic/myeloproliferative disease:
- PO 400mg OD
- PO 400mg OD
- Aggressive systemic mastocytosis:
- PO 400mg OD
- PO 400mg OD
- Hypereosinophilic syndrome (HES) and/or chronic eosinophilic leukemia (CEL):
- PO 400mg OD
- PO 400mg OD
- Unresectable, recurrent and/or metastatic dermatofibrosarcoma protuberans:
- PO 400mg BD
- PO 400mg BD
- Adjuvant treatment in Kit-positive gastrointestinal stromal tumor :
- PO 400mg OD *3 years
- Tablet:
- 100mg
- 400mg
- Taken with meals
Kinase inhibitors anticancer
It inhibits Philadelphia chromosomal tyrosine kinase and myeloid leukemic cell proliferation thereby inducing apoptosis
- Fluid retention
- Peripheral edema
- Periorbital edema
- Nausea & vomiting
- Diarrhea
- Myalgia
- Musculoskeletal pain
- Abdominal pain
- Fatigue
- Rash
- Fever
- Headache
- Anemia
- Thrombocytopenia
- Hemorrhage
- Arthralgia
- Neutropenia
- Dyspepsia
- Cough
- Elevated ALT/AST
- Bilirubin elevated
- URI
- Hypokalemia
- Dizziness
- Constipation
- Pruritus
- Anorexia
- Photosensitivity
- Hypersensitivity to components
- Pregnancy
- Breastfeeding during treatment and for 1 month after discontinuing
- Cobimetinib
- Conivaptan
- Dihydroergotamine
- Dihydroergotamine intranasal
- Eliglustat
- Flibanserin
- Ivabradine
- Lomitapide
- Lonafarnib
- Lurasidone
- Naloxegol
- Regorafenib
- Venetoclax
Drug Status
| Availability | Prescription only |
| Pregnancy | Category B |
| Breastfeeding | Contraindicated |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Glivec | 100mg | Tablet | 120’s | Novartis Pharma | Novartis Kenya |
| Glivec | 400mg | Tablet | 90’s | Novartis Pharma | Novartis Kenya |