- Advanced prostrate cancer:
- SC 3.6mg every month OR 10.8mg every 3 months
- SC 3.6mg every month OR 10.8mg every 3 months
- Palliative treatment in advanced breast cancer:
- SC 3.6mg every month OR 10.8mg every 3 months
- SC 3.6mg every month OR 10.8mg every 3 months
- Endometriosis:
- SC 3.6mg every month *6/12
- SC 3.6mg every month *6/12
- Endometrial thinning:
- SC 3.6mg every month *1-2 doses
- Implant in pre-filled syringe:
- 3.6mg
- 10.8mg
- Placed in upper abdominal wall
Gonadotropin-releasing hormone (LHRH) Agonist
It inhibits gonadotropin release, suppressing ovarian and testicular steroidogenesis
- Hot flashes
- Headache
- Vaginitis
- Sexual dysfunction
- Emotional lability
- Depression
- Diaphoresis
- Acne
- Transient tumor flare
- Edema
- Breast changes
- Breast pain
- Seborrhea
- Urogenital disorders
- Pain
- Asthenia
- Malaise
- Lethargy
- URI
- Application site reaction
- Insomnia
- Nausea
- Dizziness
- Hypertension
- Anorexia
- Rash
- Hypercalcemia
- Hypersensitivity to class/components
- Pregnancy (endometrial thinning or endometriosis use)
- Amiodarone
- Anagrelide
- Arsenic trioxide
- Artemether
- Artemether/lumefantrine
- Citalopram
- Disopyramide
- Dofetilide
- Dronedarone
- Eliglustat
- Escitalopram
- Fluoxetine
- Ibutilide
- Iloperidone
- Lopinavir
- Lumefantrine
- Mifepristone
- Nilotinib
- Paliperidone
- Pimozide
- Procainamide
- Quetiapine
- Quinidine
- Sotalol
- Tetrabenazine
- Thioridazine
- Toremifene
- Vandetanib
- Vemurafenib
- Ziprasidone
Drug Status
| Availability | Prescription only |
| Pregnancy | Category X |
| Breastfeeding | Not recommended |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Zoladex Depot | 3.6mg | Implant in Pre-Filled Syringe | 1’s | AstraZeneca | AstraZeneca |
| Zoladex LA | 10.8mg | Implant in Pre-Filled Syringe | 1’s | AstraZeneca | AstraZeneca |