• Rheumatoid Arthritis (RA) – with methotrexate
  • Psoriatic Arthritis (PsA)
  • Ankylosing Spondylitis (AS)

Dose:

Simponi (Subcutaneous):

  • RA, PsA, AS:50 mg SC once monthly,For RA: Use with methotrexate

Simponi Aria (Intravenous):

  • RA, PsA, AS:2 mg/kg IV over 30 minutes at 0 and 4 weeks, then every 8 weeks,Given with methotrexate for RA
  • Ulcerative Colitis (UC) – moderate to severe (adults only)

Dose:

Induction: 200 mg SC at week 0, 100 mg at week 2

Maintenance: 100 mg SC every 4 weeks

  • Subcutaneous (SC):
    • Auto-injector or prefilled syringe: 50 mg/0.5 mL, 100 mg/1 mL
  • IV formulation (Simponi Aria):
    • Vial: 50 mg/4 mL
  • SC injections: Administer once a month, rotate sites (thigh, abdomen, upper arm)
  • IV infusions: Must be given by a healthcare provider
  • Refrigerate both forms; bring SC to room temperature before use
  • Do not shake or freeze
  • Class: Human IgG1κ monoclonal antibody
  • Mechanism of Action:
    • Binds TNF-α, preventing interaction with receptors → reduces inflammation
    • ↓ cytokine activity → ↓ immune cell activation and migration
  • Half-life: ~14 days
  • Onset: Weeks 2–6
  • Excretion: Not fully characterized
  • Upper respiratory infections
  • Injection site reactions
  • Headache
  • Fatigue
  • Nausea
  • Dizziness
  • Moderate to severe heart failure (NYHA Class III/IV, for IV formulation)
  • Active severe infections
  • Hypersensitivity to golimumab or components
  • Avoid live vaccines
  • Avoid combination with other biologics (e.g., adalimumab, etanercept)
  • May be used with methotrexate or NSAIDs
  • Monitor closely with immunosuppressants (↑ infection risk)

                                   Drug Status

Availability
Pregnancy
Breastfeeding
Schedule
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Simponi 50mg/0.5mL Injection 1’s Janssen Biologics Janssen Biologics
Simponi 100mg/mL Injection 1’s Janssen Biologics Janssen Biologics