- Advanced ovarian cancer that has relapsed at least 6 months after completion of platinum-based therapy:
- 1000mg/m² IV infusion over 30 minutes on Days 1 and 8 of each 21-day cycle
- Combined with cisplatin
- Non-small cell lung cancer:
- 1000mg/m² IV infusion over 30 minutes on days 1, 8, and 15 of each 28-day cycle OR 1250mg/m² IV infusion over 30 minutes on days 1 and 8 of each 21-day cycle
- Administer cisplatin 100 mg/m² IV after gemcitabine on day 1
- Pancreatic cancer:
- 1000 mg/m² IV infusion over 30 min once weekly *7/52, rest 1 week, then 1000mg/m² once weekly *3/52 of each 28-day cycle
- Monotherapy or combination therapy
- Breast cancer:
- 1250mg/m² IV infusion over 30 minutes on day 1 and 8 of each 21-day cycle
- Used with paclitaxel 175mg/m² on Day 1 as a 3 hour infusion before gemcitabine
- Infusion:
- 10mg
- 200mg
- 1000mg
Immediately wash the skin thoroughly or rinse the mucosa with copious amounts of water if drug contacts the skin or mucus membranes
Pyrimidine analog
It inhibits DNA synthesis by inhibiting the ribonucleotide reductase, cell cycle-specific for the S-phase of the cycle
- Nausea
- Vomiting
- Proteinuria
- Fever
- Hematuria
- Rash
- Neutropenia
- Dyspnea
- Peripheral edema
- Diarrhea
- Influenza-like symptoms
- Hemorrhage
- Infection
- Elevated BUN/Cr
- Alopecia
- Edema
- Stomatitis
- Somnolence
- Paresthesia
- Elevated LFTs
- Anemia
- Thrombocytopenia
- Injection site reaction
- Hypersensitivity to drug/compound
- Radiotherapy within 7 days
- Pregnancy 1st trimester
- Live bacterial vaccines
Drug Status
| Availability | Prescription only |
| Pregnancy | Category D |
| Breastfeeding | Contraindicated |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Abingem | 200mg | Injection | 1’s | Miracalus | Ripple Pharma |
| Abingem | 1g | Injection | 1’s | Miracalus | Ripple Pharma |
| Amgicin | 1000mg | Injection | 1’s | Galaxy Pharma | Galaxy Pharma |
| Biogem | 200mg | Injection | 1’s | United Biotech | Salama Pharma |
| Biogem | 1g | Injection | 1’s | United Biotech | Salama Pharma |
| Celzar | 1g | Injection | 1’s | Celon Labs | Europa Healthcare |
| Chemogem | 200mg | Injection | 1’s | Atlanta Biologicals | Synermed Pharma |
| Chemogem | 1g | Injection | 1’s | Atlanta Biologicals | Synermed Pharma |
| Citabol | 200mg | Injection | 1’s | Venus Remedies | Surgipharm Ltd |
| Citabol | 1g | Injection | 1’s | Venus Remedies | Surgipharm Ltd |
| Citafine | 1g | Injection | 1’s | Emcure Pharma | Lazor Pharma |
| Gemcirex | 200mg | Injection | 1’s | Innorex Pharma | Sai Pharma |
| Gemcirex | 1g | Injection | 1’s | Innorex Pharma | Sai Pharma |
| Gemita | 1g | Injection | 1’s | Fresenius Kabi | Nairobi Enterprises |
| Gemflox | 320mg | Tablet | 5's | Krishna Chemists | Krishna Chemists |
| Gempower | 1g | Injection | 1’s | PSM Pharma | PSM Pharma |
| Gempower | 200mg | Injection | 1’s | PSM Pharma | PSM Pharma |
| Gemtero | 200mg | Injection | 1’s | Hetero Labs | Unisel Ltd |
| Gemtero | 1g | Injection | 1’s | Hetero Labs | Unisel Ltd |