- Testicular cancer:
- IV 50-100mg/m²/day on days 1-5 OR IV 100mg/m²/day on days 1, 3, 5
- Repeat every 3-4 weeks
- Part of multi-drug chemo regimen
- Small cell lung cancer:
- IV 35mg/m²/day *4/7 OR 50mg/m²/day *5/7
- PO 70mg/m²/dose/day *4/7 to 100mg/m²/day OD *5/7
- Repeat every 3-4 weeks
- Round-off PO to nearest 50mg
- Part of multi-drug chemo regimen
Capsule: 100mg
Injection: 100mg/5mL
- Monitor for crystallization
Podophyllotoxin anticancer
It appears to inhibit or alter DNA replication, induces G2-phase arrest and preferentially kills cells in G2 & late S phases
- Leukopenia
- Neutropenia
- Alopecia
- Nausea
- Vomiting
- Thrombocytopenia
- Anemia
- Anorexia
- Diarrhea
- Stomatitis
- Mucositis
- Abdominal pain
- Peripheral neurotoxicity
- Hypersensitivity reaction
- Hypotension
- Fever
- Rigors
- Taste changes
- Constipation
- Extravasation
- Hypersensitivity to class/components
- Avoid breastfeeding during treatment and for 72 hours after discontinuing
- Pregnancy 1st trimester
- Talimogene
- Live bacterial vaccines
Drug Status
| Availability | Prescription only |
| Pregnancy | Category D |
| Breastfeeding | Contraindicated |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Bioposide | 100mg/5mL | Injection | 1’s | Zydus Healthcare | Sai Pharma |
| Fytosid | 100mg/5mL | Injection | 1’s | Fresenius Kabi | Nairobi Enterprises |
| Sedol | 100mg/5mL | Injection | 1’s | Venus Remedies | Surgipharm Ltd |