- Advanced testicular cancer:
- IV 20mg/m²/day *5/7 repeated every 3 weeks (in combination with bleomycin and etoposide)
- IV 20mg/m²/day *5/7 repeated every 3 weeks (in combination with bleomycin and etoposide)
- Advanced ovarian cancer:
- IV 75-100mg/m² *1 every 4 weeks with cyclophosphamide (IV 600mg/m² every 4 weeks)
- Administered sequentially
- Administered sequentially
- IV 75-100mg/m² *1 every 4 weeks with cyclophosphamide (IV 600mg/m² every 4 weeks)
-
- Off-label: 90-270mg/m² intra-peritoneal
- Retain for 4 hours before draining
- Repeat every 3 weeks (may co-administer systemic Na thiosulfate)
- Off-label: 90-270mg/m² intra-peritoneal
- Advanced bladder cancer:
- IV 50-70mg/m² *1 every 3-4 weeks, depending on prior radiation therapy or chemotherapy
- Heavily pretreated patients: 50mg/m²/cycle initially repeated every 4 weeks
- Max: 100mg/m²/cycle
- Advanced cervical cancer (Off-label):
- IV 75-100mg/m² every 4 weeks when used with cyclophosphamide
- IV 100mg/m² every 4 weeks as single agent
Injection: 50mg/50mL
- Pre-treatment hydration: 1-2L fluid infused for 8-12 hours before dose
- Adequate hydration and urine output to be maintained before, during and 24 hours after dose
- May use concomitant amifostine to decrease nephrotoxicity
- When administered as sequential infusions, taxane derivatives (docetaxel, paclitaxel) should be administered before platinum derivatives to limit myelosuppression and to enhance efficacy
Alkylating agent; Platinum analog
It binds and crosslinks DNA disrupting DNA function
- Nausea & vomiting
- Anorexia
- Elevated BUN or Cr
- Nephrotoxicity
- Hyperuricemia
- Tinnitus
- Hearing loss
- Myelosuppression
- Thrombocytopenia
- Anemia
- Electrolyte disorders
- Elevated LFTs
- Neurotoxicity
- Peripheral neuropathy
- Paresthesia
- Muscle cramps
- Blurred vision
- Altered color perception
- Rash
- Loss of taste
- Alopecia
- Malaise
- Asthenia
- Diarrhea
- Hiccups
- Hypersensitivity to class/components
- Hypersensitivity to platinum compounds
- Breastfeeding
- Avoid during dose and for up to 14 months after last dose in both males and females
WARNING:
- Peripheral neuropathy
- Severe nausea & vomiting. Pre-treatment with an antiemetic required; may begin within 1-4 hours after treatment and last up to 72 hours
- Live bacterial vaccines
- Cidofovir
Drug Status
| Availability | Prescription only |
| Pregnancy | Category D |
| Breastfeeding | Contraindicated |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Adcist | 50mg/50mL | Injection | 1’s | Galaxy Pharma | Galaxy Pharma |
| Ciscord | 50mg | Injection | 1’s | Intas Pharma | Accord Healthcare |
| Cisplat | 50mg/50mL | Injection | 1’s | Zydus Healthcare | Sai Pharma |
| Cispole | 50mg | Injection | 1s | Atlanta Biologicals | Synermed Pharma |
| Cytolast | 50mg/50mL | Injection | 1’s | Cipla Ltd | Imperial Managed |
| Platinex | 50mg/50mL | Injection | 1’s | PSM Pharma | PSM Pharma |
| Platol | 50mg/100mL | Injection | 1’s | Venus Remedies | Surgipharm Ltd |
| Platol | 10mg/20mL | Injection | 1’s | Venus Remedies | Surgipharm Ltd |