- Advanced ovarian carcinoma:
- Monotherapy:
- IV 360mg/m² *1 every 4 weeks
- Monotherapy:
-
- Combination treatment:
- IV 300mg/m² (plus IV cyclophosphamide 600mg/m²) *1 every 4 weeks
- Combination treatment:
Injection:
- 150mg/15mL
- 450mg/45mL
- Administer IV over 15 min or continuous IV infusion over 24 hours
- Can be administered intraperitoneally
- When administered as sequential infusions, taxane derivatives (docetaxel, paclitaxel) should be administered before platinum derivatives to limit myelosuppression and to enhance efficacy
- Do not use aluminum-containing needles because aluminum can cause precipitate formation and loss of potency
- Do not use IV administration sets that may come in contact with carboplatin
Alkylating antineoplastic agent; Platinum analog
It binds and crosslinks DNA
- Thrombocytopenia
- Anemia
- Leukopenia
- Nausea
- Vomiting
- Hypomagnesemia
- Hyponatremia
- Hypokalemia
- Hypocalcemia
- Elevated Alk phos
- Elevated LFTs
- Elevated BUN/Cr
- Pain
- Asthenia
- Paresthesia
- Abdominal pain
- Diarrhea
- Constipation
- Mucositis
- Peripheral neuropathy
- Neurotoxicity
- Bleeding
- Alopecia
- Injection site reaction
- Hypersensitivity to class/components
- Hypersensitivity to mannitol, cisplatin and platinum compounds
- Pregnancy 1st trimester
- Breastfeeding
- Myelosuppression
- Active bleeding
- Cidofovir
- Live bacterial vaccines
Drug Status
| Availability | Prescription only |
| Pregnancy | Category D |
| Breastfeeding | Contraindicated |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Adcarb | 450mg/45mL | Injection | 1’s | Galaxy Pharma | Galaxy Pharma |
| Biocarb | 450mg/45mL | Injection | 1’s | Zydus Healthcare | Sai Pharma |
| Biocarb | 150mg/15mL | Injection | 1’s | Zydus Healthcare | Sai Pharma |
| Carbol | 450mg/45mL | Injection | 1’s | Venus Remedies | Surgipharm Ltd |
| Carbol | 150mg/15mL | Injection | 1’s | Venus Remedies | Surgipharm Ltd |
| Carbopa | 150mg/15mL | Injection | 1’s | Intas Pharma | Accord Healthcare |
| Carbopa | 150mg/15mL | Injection | 1’s | Intas Pharma | Accord Healthcare |
| Carbotin | 450mg/45mL | Injection | 1’s | Getwell Pharma | Nairobi Enterprises |
| Carbotin | 450mg/45mL | Injection | 1’s | Getwell Pharma | Nairobi Enterprises |
| Kemocarb | 150mg/15mL | Injection | 1’s | Fresenius Kabi Oncology | Nairobi Enterprises |
| Kemocarb | 450mg/15mL | Injection | 1’s | Fresenius Kabi Oncology | Nairobi Enterprises |
| Oplat | 450mg/45mL | Injection | 1’s | Glenmark Pharma | Glenmark Pharma |
| Oplat | 150mg/15mL | Injection | 1’s | Glenmark Pharma | Glenmark Pharma |
| Womastin | 150mg | Injection | 1’s | PSM Pharma | PSM Pharma |
| Womastin | 450mg | Injection | 1’s | PSM Pharma | PSM Pharma |