• Nasal congestion due to:

    • Common cold

    • Sinusitis

    • Allergic rhinitis

    • Hay fever

    • Upper respiratory tract infections

Dosage:

  • Adults & children ≥12 years:
    0.1% nasal drops/spray: 1–2 sprays/drops in each nostril, every 8–10 hours (Max 3 times/day)

  • Children 2–12 years:
    0.05% nasal drops/spray: 1–2 sprays/drops per nostril, every 8–10 hours

⚠️ Do not use for more than 5–7 consecutive days to avoid rebound congestion (rhinitis medicamentosa)

  • 0.1% solution: Adults & children ≥12 years

  • 0.05% solution: Children 2–12 years

  • Clear nostrils before use

  • Tilt head slightly forward

  • Insert spray nozzle or dropper gently into the nostril

  • Administer while inhaling gently

  • Avoid sharing to prevent contamination

  • Class: Nasal decongestant (Sympathomimetic)

  • Mechanism of Action:
    Alpha-adrenergic agonist → vasoconstriction of nasal mucosa blood vessels → reduced swelling/congestion

  • Onset: 5–10 minutes

  • Duration: Up to 10–12 hours

  • Common (local):

    • Nasal dryness

    • Burning/stinging

    • Sneezing

  • Less common (systemic, if overused):

    • Headache

    • Nausea

    • Palpitations

    • Hypertension

  • Hypersensitivity to xylometazoline or excipients

  • Narrow-angle glaucoma

  • Recent nasal surgery or trauma

  • Atrophic rhinitis

  • Children under 2 years of age (due to risk of systemic effects)

  • MAO Inhibitors:
    Risk of hypertensive crisis – avoid concurrent use

  • Tricyclic Antidepressants (TCAs):
    May enhance sympathomimetic effect

  • Other decongestants/sympathomimetics:
    Additive effects may increase cardiovascular risk

                                   Drug Status

Availability
Pregnancy
Breastfeeding
Schedule
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Ivynozvin A 0.1% w/v Nasal Drops 10mL Ivee Aqua B Braun Pharma
Ivynozvin P 0.05% w/v Nasal Drops 10mL Ivee Aqua B Braun Pharma
Otrivin Adult 0.1% w/v Nasal Drops 10mL GSK Ltd GSK Ltd
Otrivin Children 0.05% w/v Nasal Drops 10mL GSK Ltd GSK Ltd
Rhinovin Adult 0.1% w/v Nasal Drops 10mL Biodeal Labs Biodeal Labs
Rhinovin Paediatric 0.05% w/v Nasal Drops 10mL Biodeal Labs Biodeal Labs
Sinutab Nasal Spray 0.1% w/v Nasal Spray 10mL Johnson & Johnson Surgipharm Ltd
Xylo-Acino 0.05% 0.05% w/v Nasal Spray 10mL Acino Pharma Goodman Agencies
Xylo-Acino 0.1% 0.1% w/v Nasal Spray 10mL Acino Pharma Goodman Agencies
Xylolin Adult 0.1% w/v Nasal Spray 10mL Julphar Pharma Pharmamed Solution
Xylolin Child 0.05% w/v Nasal Spray 10mL Julphar Pharma Pharmamed Solution