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Nasal congestion due to:
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Common cold
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Sinusitis
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Allergic rhinitis
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Hay fever
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Upper respiratory tract infections
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Dosage:
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Adults & children ≥12 years:
0.1% nasal drops/spray: 1–2 sprays/drops in each nostril, every 8–10 hours (Max 3 times/day) -
Children 2–12 years:
0.05% nasal drops/spray: 1–2 sprays/drops per nostril, every 8–10 hours
⚠️ Do not use for more than 5–7 consecutive days to avoid rebound congestion (rhinitis medicamentosa)
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0.1% solution: Adults & children ≥12 years
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0.05% solution: Children 2–12 years
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Clear nostrils before use
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Tilt head slightly forward
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Insert spray nozzle or dropper gently into the nostril
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Administer while inhaling gently
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Avoid sharing to prevent contamination
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Class: Nasal decongestant (Sympathomimetic)
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Mechanism of Action:
Alpha-adrenergic agonist → vasoconstriction of nasal mucosa blood vessels → reduced swelling/congestion -
Onset: 5–10 minutes
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Duration: Up to 10–12 hours
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Common (local):
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Nasal dryness
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Burning/stinging
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Sneezing
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Less common (systemic, if overused):
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Headache
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Nausea
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Palpitations
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Hypertension
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Hypersensitivity to xylometazoline or excipients
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Narrow-angle glaucoma
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Recent nasal surgery or trauma
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Atrophic rhinitis
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Children under 2 years of age (due to risk of systemic effects)
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MAO Inhibitors:
Risk of hypertensive crisis – avoid concurrent use -
Tricyclic Antidepressants (TCAs):
May enhance sympathomimetic effect -
Other decongestants/sympathomimetics:
Additive effects may increase cardiovascular risk
Drug Status
Availability | |
Pregnancy | |
Breastfeeding | |
Schedule |
BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
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Ivynozvin A | 0.1% w/v | Nasal Drops | 10mL | Ivee Aqua | B Braun Pharma |
Ivynozvin P | 0.05% w/v | Nasal Drops | 10mL | Ivee Aqua | B Braun Pharma |
Otrivin Adult | 0.1% w/v | Nasal Drops | 10mL | GSK Ltd | GSK Ltd |
Otrivin Children | 0.05% w/v | Nasal Drops | 10mL | GSK Ltd | GSK Ltd |
Rhinovin Adult | 0.1% w/v | Nasal Drops | 10mL | Biodeal Labs | Biodeal Labs |
Rhinovin Paediatric | 0.05% w/v | Nasal Drops | 10mL | Biodeal Labs | Biodeal Labs |
Sinutab Nasal Spray | 0.1% w/v | Nasal Spray | 10mL | Johnson & Johnson | Surgipharm Ltd |
Xylo-Acino 0.05% | 0.05% w/v | Nasal Spray | 10mL | Acino Pharma | Goodman Agencies |
Xylo-Acino 0.1% | 0.1% w/v | Nasal Spray | 10mL | Acino Pharma | Goodman Agencies |
Xylolin Adult | 0.1% w/v | Nasal Spray | 10mL | Julphar Pharma | Pharmamed Solution |
Xylolin Child | 0.05% w/v | Nasal Spray | 10mL | Julphar Pharma | Pharmamed Solution |