• Prophylaxis of migraine and cluster headaches
    (Not for acute treatment of migraine attacks)

Dosage:

  • Adults:
    Initial: 0.5 mg at night
    Maintenance: 1.5 mg daily (can be divided into 2–3 doses)
    Max: 3 mg/day

  • Children (>2 years):
    Starting dose: 0.25–0.5 mg at night
    Max: 1.5 mg/day, divided into 2–3 doses

  • Tablets: 0.5 mg

  • Some formulations may include 1.5 mg sustained-release tablets in certain markets

  • Usually taken at night to minimize drowsiness

  • Can be taken with or without food

  • Do not exceed prescribed dose

  • Gradual titration helps minimize side effects like drowsiness

  • Class: Serotonin (5-HT2) receptor antagonist with antihistaminic and anticholinergic properties

  • Mechanism: ➤ Inhibits serotonin (5-HT) and histamine receptors
    ➤ Prevents vasodilation and vascular permeability associated with migraines

  • Also has a weak anticholinergic and sedative effect

Common:

  • Drowsiness or sedation

  • Increased appetite

  • Weight gain

  • Dry mouth

  • Dizziness

Less Common:

  • Nausea

  • Fatigue

  • Anxiety

  • Rash

  • Hypersensitivity to pizotifen or excipients

  • Angle-closure glaucoma

  • Urinary retention, especially due to prostatic hypertrophy

  • CNS depressants (e.g., alcohol, sedatives):
    ➤ Increased sedative effect

  • MAO inhibitors:
    ➤ Avoid concurrent use (risk of hypertensive crisis or serotonin syndrome)

                                   Drug Status

Availability
Pregnancy
Breastfeeding
Schedule
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Mosegor 0.5mg/10mL Suspension 100mL Novartis Pharma Novartis Kenya