Ebastine/ Montelukast

• Ebastine 10 mg + Montelukast 10 mg (most common)
• Sometimes available in chewable or dispersible forms for children.

• Take orally once daily, with or without food.
• Montelukast is best taken in the evening, especially for asthma.
• Avoid alcohol and sedatives due to potential CNS effects.

Ebastine:

• A second-generation H1-antihistamine.
• Selectively blocks peripheral H1 receptors to relieve allergy symptoms.
• Does not significantly cross the blood-brain barrier (less sedation).

Montelukast:

• A leukotriene receptor antagonist (LTRA).
• Blocks cysteinyl leukotriene receptor type 1 (CysLT1).
• Reduces inflammation, bronchoconstriction, and mucus production in the airways.

Ebastine:

• Headache
• Dry mouth
• Drowsiness (less common)
• Fatigue

Montelukast:

• Headache
• Abdominal pain
• Diarrhea
• Neuropsychiatric events (e.g., agitation, depression, rarely suicidal thoughts)

• Hypersensitivity to either drug
• Severe hepatic impairment (Ebastine is hepatically metabolized)
• Not recommended in children under 6 months (Montelukast) or under 12 years (Ebastine tablets)

Ebastine:

• Increased risk of QT prolongation with ketoconazole, erythromycin, or other CYP3A4 inhibitors.
• Alcohol and CNS depressants may increase sedation.

Montelukast:

• Minimal drug interactions.
• Enzyme inducers like rifampin may reduce its efficacy.