Desloratadine/ Montelukast

• Desloratadine 5 mg + Montelukast 10 mg (Adults)
• Pediatric combinations are often adjusted (e.g., Desloratadine 2.5 mg + Montelukast 4/5 mg)

• Take orally once daily, preferably in the evening (especially for asthma/allergy control)
• Can be taken with or without food
• Consistency is important—take at the same time each day

Desloratadine:

• A non-sedating, long-acting H1-antihistamine
• Blocks histamine (H1) receptors to relieve allergic symptoms
• Does not easily cross the blood-brain barrier (less drowsiness)

Montelukast:

• A leukotriene receptor antagonist (LTRA)
• Inhibits the effects of leukotrienes involved in allergic and inflammatory processes (e.g., bronchoconstriction, mucosal edema)

Desloratadine:

• Headache
• Dry mouth
• Fatigue
• Dizziness (rare)

Montelukast:

• Headache
• Abdominal pain
• Diarrhea
• Neuropsychiatric effects: mood changes, agitation, anxiety, depression (rare but serious)

• Hypersensitivity to either Desloratadine or Montelukast
• Severe liver impairment (use caution with Montelukast)
• Not for acute asthma attacks

• Montelukast: Metabolized by CYP3A4 and 2C9—enzyme inducers (e.g., rifampin, phenytoin) may reduce its effect
• Desloratadine: Fewer interactions; minimal CYP metabolism, but caution with other sedatives
• Avoid combining with other antihistamines or leukotriene receptor antagonists