- Severe fungal infections:
- Adults and >15 years:
- Initially IV 6mg/kg/dose BD *2 doses then 4mg/kg/dose BD
- May switch to PO 200mg BD after 7 days of IV treatment
- Adults and >15 years:
-
- 2-14 years (<50kg):
- IV 9mg/kg/dose BD *2 doses then 8mg/kg/dose BD
- May switch to PO 9mg/kg/dose BD after 7 days of IV treatment
- Max PO 350mg BD
- 2-14 years (<50kg):
- Invasive aspergillosis:
- Adults and >15 years:
- Initially IV 6mg/kg/dose BD *2 doses then 4mg/kg/dose BD
- May switch to PO 200mg BD after 7 days of IV treatment
- Adults and >15 years:
-
- 2-14 years (<50kg):
- IV 9mg/kg/dose BD *2 doses then 8mg/kg/dose BD
- May switch to PO 9mg/kg/dose BD after 7 days of IV treatment
- Max PO 350mg BD
- 2-14 years (<50kg):
- Candidemia in non-neutropenic patients with other deep tissue Candida infections:
- Adults: Initially IV 6mg/kg/dose BD *2 doses then 3-4mg/kg/dose BD
- Treat for 14 days after symptoms resolution or last positive culture
- May switch to PO 200mg BD anytime after day 1
- Adults: Initially IV 6mg/kg/dose BD *2 doses then 3-4mg/kg/dose BD
-
- 2-14 years (<50kg):
- IV 9mg/kg/dose BD *2 doses then 8mg/kg/dose BD
- May switch to PO 9mg/kg/dose BD after 7 days of IV treatment
- Max PO 350mg BD
- 2-14 years (<50kg):
- Esophageal candidiasis:
- Adults (<40 kg):
- PO 100mg BD OR IV 3mg/kg/dose BD
- PO 100mg BD OR IV 3mg/kg/dose BD
- Adults (<40 kg):
-
- Adults (>40kg):
- PO 200mg BD OR IV 3mg/kg/dose BD
- PO 200mg BD OR IV 3mg/kg/dose BD
- Adults (>40kg):
-
- 2-14 years (<50kg):
- PO 9mg/kg/dose BD. Max: 350mg BD OR IV 4mg/kg/dose BD
- Treat for 14 days minimum and for 7 days after symptoms resolution
- 2-14 years (<50kg):
- Oropharyngeal candidiasis (Off-label):
- PO 200mg BD
- For fluconazole-refractory disease
- Fungal endophthalmitis:
- Adults and ≥2 years: 50-100mcg in 0.1mL sterile water intravitreally *1
- Part of multi-drug regimen
Tablet: 200mg
Injection: 200mg
- Infuse IV over 1-2 hours, not to exceed 3mg/kg/hour
- Take oral form 1 hour before or after meal
Triazole antifungals
It binds to lanosterol 14 alpha-demethylase inhibiting ergosterol synthesis and disrupting fungal cell membrane integrity
- Visual disturbance
- Fever
- Rash
- Nausea
- Vomiting
- Rigors
- Diarrhea
- Headache
- Sepsis
- Peripheral edema
- Abdominal pain
- Respiratory disorders
- Elevated Alk phos
- Elevated ALT/AST
- Hyperbilirubinemia
- Hallucinations
- Tachycardia
- Photophobia
- Color vision changes
- Photosensitivity
- Alopecia
- Constipation (peds patients)
- Dizziness (peds patients)
- Hypertension (peds patients)
- Hypokalemia (peds patients)
- Hypotension (peds patients)
- Hypocalcemia (peds patients)
- Hyperglycemia (peds patients
- Hypophosphotemia (peds patients)
- Hypoalbuminemia (peds patients)
- Hypomagnesemia (peds patients)
- Hypersensitivity to class/components
- Pregnancy
- CrCl <50 (IV use)
- Galactose intolerance (tab form)
- Lapp lactase deficiency (tab form)
- Glucose malabsorption (tab form)
- Galactose malabsorption (tab form)
- Uncorrected electrolyte abnormalities
- Alfuzosin
- Alprazolam
- Butabarbital
- Butalbital
- Carbamazepine
- Cisapride
- Colchicine
- Conivaptan
- Dihydroergotamine
- Dronedarone
- Efavirenz
- Eliglustat
- Eplerenone
- Ergotamine
- Finerenone
- Flibanserin
- Isavuconazonium
- Ivabradine
- Lomitapide
- Lonafarnib
- Lovastatin
- Lurasidone
- Mavacamten
- Naloxegol
- Pacritinib
- Pentobarbital
- Phenobarbital
- Pimozide
- Primidone
- Quinidine (antiarrhythmic)
- Ranolazine
- Rifabutin
- Rifampin
- Ritonavir
- Silodosin
- Simvastatin
- Sirolimus
- Thioridazine
- Tolvaptan
- Ubrogepant
- Venetoclax
- Voclosporin
Drug Status
| Availability | Prescription only |
| Pregnancy | Category D |
| Breastfeeding | Weigh risk vs benefit |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Vfend | 200mg | Tablet | 30’s | Pfizer Labs | Pfizer Labs |
| Vfend | 200mg | Injection | 1’s | Pfizer Labs | Pfizer Labs |
| Vorifun | 200mg | Tablet | 12’s | Medisel Kenya | Medisel Kenya |
| Voriole | 200mg | Tablet | 10’s | MSN Labs | MSN Labs |