- Treatment of systemic candidiasis, blastomycosis, coccidioioidomycosis, histoplasmosis, chromomycosis and paracoccidioidomycosis.
- Treatment of severe recalcitrant cutaneous dermatophyte infections not responding to topical therapy or oral griseofulvin.
-
- Adults and children >30kg: 200mg OD OR 400mg OD in severe infections. Max 1.2g/day
- Children >2 years:3-6.6mg/kg daily.
- Resistant vaginal candidiasis:
- 200-400mg *1/52
Tablet: 200mg
Shampoo: 2%
- Tablets to be taken with food.
- Duration of treatment varies with severity of infection.
Systemic imidazole antifungal.
It binds to lanosterol 14 alpha-demethylase, inhibiting ergosterol synthesis and disrupting fungal cell membrane integrity.
- Anaphylaxis
- Nausea
- Vomiting
- Pruritus
- Headache
- Lethargy
- Somnolence
- Dizziness
- Alopecia
- Decreased libido
- Photophobia
- Bulging fontanelles
- Hypersensitivity to components
- Acute/chronic liver disease
- Pregnancy
- Fungal meningitis
- Alcohol
- Anticholinergics
- Antacids
- Cimetidine
- Rifampicin
- Isoniazid
- Phenytoin
- Miconazole
- Oral hypoglycaemic agents
- Methadone
- Procainamide
- Colchicine
- Midazolam
- Alprazolam
- Simvastatin
Drug Status
| Availability | Prescription or OTC by Pharmacist |
| Pregnancy | Category C |
| Breastfeeding | Enters breast milk; not recommended |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Benzol | 200mg | Tablet | 30’s | Benmed Pharma | Benmed Pharma |
| Carenazol | 200mg | Tablet | 30’s | Careplus Ltd | Careplus Ltd |
| Dermizol | 200mg | Tablet | 30’s | Opera Pharma | Opera Pharma |
| Hitoral | 200mg | Tablet | 30’s, 100’s | Biopharma Ltd | Biopharma Ltd |
| Kecozole | 200mg | Tablet | 30’s, 100’s | Biodeal Labs | Biodeal Labs |
| Kenazole | 200mg | Tablet | 30’s | Dawa Ltd | Dawa Ltd |
| Ketarin | 200mg | Tablet | 30’s | Harley’s Ltd | Harley’s Ltd |
| Ketarin | 200mg | Tablet | 30’s | Harley’s Ltd | Harley’s Ltd |
| Ketomac | 200mg | Tablet | 30’s | Macleods Pharma | Sai Pharma |
| Ketoziral | 200mg | Tablet | 30’s, 100’s | Universal Corporation | Universal Corporation |
| Kior | 200mg | Tablet | 10’s | Metro Pharma | Metro Pharma |
| Kior | 200mg | Tablet | 10’s | Metro Pharma | Metro Pharma |
| Konazol | 200mg | Tablet | 100’s | Lincoln Pharma C/O Medox Pharma | Medox Pharma |
| Nazole | 200mg | Tablet | 30’s, 100’s | Laboratory & Allied | Laboratory & Allied |