- Vulvovaginal candidiasis
- 200 mg BD *1/1
- Tinea corporis/Tinea cruris/Tinea pedis:
- 200mg OD *1/52 subsequent courses repeated after 21-day intervals
- Pityriasis versiclor:
- 200mg OD *1/52
- Fungal keratitis:
- 200 OD *21/7
- Onychomycosis:
- 200 mg BD *1/52, subsequent courses repeated after 21-day intervals
- Toenails: 3 pulses/courses
- Fingernails: 2 pulses/courses
Tablet: 100mg
- Should be administered on a full meal.
- Women of child-bearing age should take contraception during the course of therapy and for 2 months after cessation of treatment.
Triazole antifungal with selective inhibition of the fungal sterol synthesis. It inhibits synthesis of ergosterol specifically the nitrogen in the azole ring is thought to bind to lanosterol-14-α-demethylase, a fungal cytochrome P450 enzyme, thereby inhibits conversion of lanosterol to ergosterol. This leads to increased cellular permeability and loss of cell contents.
- Elevated liver enzymes
- Nausea
- Vomiting
- Diarrhea
- Anorexia
- Pruritus
- Rash
- Orthostatic hypotension
- Headache
- Malaise
- Myalgia
- Vasculitis
- Vertigo
- Edema
- Loss of libido
- Dizziness.
- Pregnancy or women contemplating pregnancy
- Hypersensitivity reactions
- History of congestive heart failure
- Pre-existing hepatic abnormality,
- Terfenadine
- Astemizole
- Cisapride
- Triazolam
- Oral midazolam
- Quinidine
- Dofetilide
- Simvastatin
- Lovastatin
- Methadone
- Felodipine
- Eplerenone
- Ergotamine
- Antacids
- Gastric acid secretion suppressors.
Drug Status
Availability | Prescription or OTC by pharmacist |
Pregnancy | Category B3; Contraindicated |
Breastfeeding | Contraindicated |
Schedule | Not controlled |
BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
---|---|---|---|---|---|
Canditral | 100mg | Capsule | 12’s | Glenmark Pharma | Glenmark Pharma |
Eszol | 100mg | Tablet | 10’s | Kusum Healthcare | Zawadi Healthcare |
Fulcover | 100 mg | Capsule | 10’s | Saga Labs | Pharmaken Ltd |
Icon | 100mg | Capsule | 4’s | Ferozsons Labs C/O Surgilinks Ltd | Surgilinks Ltd |
Intraz | 100mg | Capsule | 4’s | Ochoa Labs | Medisel Kenya |
Itacare | 100mg | Capsule | 10’s | Micro Labs | Micro Labs |
Itracon | 100mg | Capsule | 4’s | Global Napi Pharma | Harley’s Ltd |
Itramet | 100mg | Capsule | 4’s | Metro Pharma | Metro Pharma |
Itranox | 100mg | Capsule | 4’s | Coral Labs | Signature Healthcare |
Izole | 100mg | Capsule | 4’s | Marksans Pharma | Sai Pharma |
Sporanox | 100mg | Capsule | 15’s | Janssen-Cilag | Johnson & Johnson |