ADULTS
- Vaginal candidiasis; adults & children 16-17yrs:
- Uncomplicated: 150mg STAT
- Complicated: 150 mg every 72hrs for 3 doses
- Recurrent: 150 mg OD for 10-14 days followed by 150 mg once weekly for 6 months
- Oropharyngeal candidiasis:
- 200 mg STAT on Day 1, THEN 100 mg OD *2/52
- Esophageal candidiasis:
- 200 mg STAT on Day 1, THEN 100 mg OD *3/52
- Cryptococcal meningitis:
- 400 mg STAT on Day 1, THEN 200 mg OD *12/52
- Tinea corporis/Tinea cruris/Tinea pedis:
- 150mg STAT per week *4-6/52
CHILDREN >1 YR
- Superficial candidiasis: 1-2mg/kg daily
- Systemic candidiasis & cryptococcal infection: 3-6mg/kg daily
1yr (9kg): 2.5ml
1-2 yrs. (12kg): 5ml
2-3yrs (14kg): 7.5ml
3-4 yrs. (16kg): 10ml
4-6 yrs. (20kg): 12.5ml
Tablets:
- 50mg
- 100mg
- 150mg
Suspension:
- 10mg/mL
Injection:
- 2mg/mL
- Can be taken with/without food.
Triazole antifungal with selective inhibition of the fungal sterol synthesis.
It inhibits synthesis of ergosterol specifically the nitrogen in the azole ring is thought to bind to lanosterol-14-α-demethylase, a fungal cytochrome P450 enzyme, thereby inhibits conversion of lanosterol to ergosterol. This leads to increased cellular permeability and loss of cell contents.
Generally well tolerated.
- Hypersensitivity reaction e.g. rash
- Headache
- Nausea & vomiting
- Diarrhea
- Abdominal pain
- Alopecia.
Hypersensitivity to azoles.
- Coumarin drugs
- Cyclosporine
- Zidovudine
- Erythromycin
- Warfarin
- Sulphonylureas
- Phenytoin
- Rifampicin
Drug Status
| Availability | Prescription or OTC by pharmacist |
| Pregnancy | Category B3; Contraindicated |
| Breastfeeding | Contraindicated |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Candican | 0.2% w/v | Injection | 100mL | Amanta Healthcare C/O Surgilinks | Surgilinks Ltd |
| Candinil | 50mg | Capsule | 30’s | Healthcare Pharma | Nextgen Pharma |
| Candinil | 150mg | Capsule | 1’s | Healthcare Pharma | Nextgen Pharma |
| Candinil | 50mg/5mL | Suspension | 35mL | Healthcare Pharma | Nextgen Pharma |
| Candizole | 150mg | Capsule | 1’s | Regal Pharma | Regal Pharma |
| Candizole | 200mg | Capsule | 10’s | Regal Pharma | Regal Pharma |
| Criptocan | 50mg/5mL | Suspension | 35mL | Sphinx Pharma | Sphinx Pharma |
| Cytcan | 150mg | Capsule | 1’s | Signature Healthcare | Signature Healthcare |
| Cytcan | 200mg | Capsule | 4’s | Coral Labs | Signature Healthcare |
| Diconazol | 200mg | Tablet | 100’s | Cosmos Ltd | Cosmos Ltd |
| Diconazol | 50mg | Tablet | 100’s | Cosmos Ltd | Cosmos Ltd |
| Diconazol | 150mg | Tablet | 1’s | Cosmos Ltd | Cosmos Ltd |
| Diflucan | 2mg/mL | Injection | 50mL, 100mL | Pfizer Labs | Pfizer Labs |
| Diflucan | 150mg | Capsule | 1’s | Pfizer Labs | Pfizer Labs |
| Diflucan | 50mg | Capsule | 7’s | Pfizer Labs | Pfizer Labs |
| Diflucan | 200mg | Capsule | 7’s | Pfizer Labs | Pfizer Labs |
| Fc-Zole | 50mg/5mL | Suspension | 60mL | Pharma Life Science | Pharma Life Science |
| Fc-Zole | 200mg | Tablet | 10’s | Pharma Life Science | Pharma Life Science |
| Fc-Zole | 150mg | Tablet | 1’s | Pharma Life Science | Pharma Life Science |
| FCN | 150mg | Tablet | 1’s | Intas Pharma | Accord Healthcare |
| Flucan | 150mg | Capsule | 1’s | Lincoln Pharma C/O Medox Pharma | Medox Pharma |
| Flucan | 200mg | Capsule | 10’s | Lincoln Pharma C/O Medox Pharma | Medox Pharma |
| Flucariv | 150mg | Capsule | 1’s | Riva Pharma S.A.E | Salama Pharma |
| Flucaz | 200mg | Capsule | 10’s | Agio Pharma | Sai Pharma |
| Fluco-Life | 200mg | Injection | 100mL | Zawadi Healthcare | Zawadi Healthcare |
| Flucodeal | 50mg | Capsule | 100’s | Biodeal Labs | Biodeal Labs |
| Flucodeal | 150mg | Capsule | 1’s | Biodeal Labs | Biodeal Labs |
| Flucodeal | 200mg | Capsule | 10’s | Biodeal Labs | Biodeal Labs |
| Flucomed | 150mg | Capsule | 1’s | Medico Remedies | Harley’s Ltd |
| Flucona-Denk | 150mg | Capsule | 1’s | Denk Pharma | Laborex Kenya |
| Fluconazole | 150mg | Tablet | 1’s | Macleods Pharma | Sai Pharma |
| Fluconazole-UF | 2mg/mL | Injection | 100mL | Yuria Pharma Ltd | Harley’s Ltd |
| Flucozal | 50mg | Capsule | 1’s | Delorbis Pharma | Europa Healthcare |
| Flucozal | 150mg | Capsule | 1’s | Delorbis Pharma | Europa Healthcare |
| Flucozal | 200mg | Capsule | 10’s | Delorbis Pharma | Europa Healthcare |
| Flugal | 150mg | Capsule | 1’s | Square Pharma | Ace Pharma |
| Flugal | 200mg | Capsule | 10’s | Square Pharma | Ace Pharma |
| Flugal | 50mg | Capsule | 30’s | Square Pharma | Ace Pharma |
| Flugal | 50mg/5mL | Suspension | 35mL | Square Pharma | Ace Pharma |
| Flutrox | 150mg | Capsule | 1’s | Universal Corporation | Universal Corporation |
| Flutrox | 200mg | Capsule | 10’s | Universal Corporation | Universal Corporation |
| Flutrox DPS | 10mg/mL | Suspension | 35mL | Universal Corporation | Universal Corporation |
| Fredluco | 150mg | Capsule | 1’s | Crown Healthcare | Crown Healthcare |
| Fucol | 200mg/100mL | Injection | 1’s | Cipla Ltd | Imperial Managed |
| Fuconzol | 150mg | Capsule | 1’s | Careplus Ltd | Careplus Ltd |
| Funasis | 150mg | Tablet | 1’s | KNVM Medicare | KNVM Medicare |
| Fungistop | 150mg | Capsule | 1’s | Fourrts Labs | Sai Pharma |
| GV-Fluc | 50mg/5mL | Suspension | 35mL | Bliss GVS | Prunus Pharma |
| Gv-Fluc | 50mg | Capsule | 10’s | Bliss GVS | Prunus Pharma |
| Omastin | 150mg | Capsule | 20’s | Beximco Pharma | Madawa Pharma |
| Omastin | 50mg | Capsule | 50’s | Beximco Pharma | Madawa Pharma |
| Omastin | 50mg/5mL | Suspension | 35mL | Beximco Pharma | Madawa Pharma |
| Sancan | 150mg | Capsule | 1’s | National Pharmacy | National Pharmacy |
| Sancan | 200mg | Capsule | 4’s | National Pharmacy | National Pharmacy |
| Ucozole | 150mg | Capsule | 1’s | Laboratory & Allied | Laboratory & Allied |
| Zolocan | 150mg | Tablet | 1’s | Meyer Organics | Harley’s Ltd |
| Zolocan | 200mg | Tablet | 10’s | Meyer Organics | Harley’s Ltd |
| Zorcan | 200mg | Capsule | 4’s, 100’s | Cipla Ltd | Lords Healthcare |
| Zorcan | 50mg | Capsule | 14’s | Cipla Ltd | Lords Healthcare |
| Zorcan | 2mg/mL | Injection | 100mL | Cipla Ltd | Lords Healthcare |
| Zorcan | 10mg/mL | Suspension | 35mL | Cipla Ltd | Lords Healthcare |