- Type 2 DM:
- Initial dose (for patients inadequately controlled on metformin): PO 50mg vildagliptin BD plus the previously prescribed dose of metformin.
-
- Initial dose (for patients switching from separate vildagliptin and metformin): Based on the current doses of vildagliptin and metformin already being taken.
-
- Max dose: PO 100mg vildagliptin per day.
Tablet:
- 50mg/500mg
- 50mg/850mg
- 50mg/1000mg
- Taken with meals to reduce gastrointestinal side effects associated with metformin.
Vildagliptin: Dipeptidyl peptidase-4 (DPP-4) inhibitor. It inhibits DPP-4, which increases incretin hormone levels (GLP-1 and GIP). This enhances insulin secretion and reduces glucagon release, improving blood glucose control.
Metformin: Biguanide. It decreases hepatic glucose production, decreases intestinal absorption of glucose and improves insulin sensitivity by increasing peripheral glucose uptake and utilisation.
- Headache
- Dizziness
- Nasopharyngitis
- Nausea
- Vomiting
- Diarrhoea
- Abdominal discomfort
- Metallic taste
- Decreased vitamin B12 levels.
- Renal impairment
- Metabolic acidosis including diabetic ketoacidosis.
- Hypersensitivity to components
Coming soon
Drug Status
| Availability | Prescription only |
| Pregnancy | Contraindicated |
| Breastfeeding | Contraindicated |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Agilismet | 50mg/850mg | Tablet | 30’s | Novartis Pharma | Novartis Kenya |
| Galvus Met | 50mg/1g | Tablet | 30’s | Novartis Pharma | Novartis Kenya |
| Galvus Met | 50mg/500mg | Tablet | 30’s | Novartis Pharma | Novartis Kenya |
| Glucowell-Met | 50mg/1g | Tablet | 28’s | Cosmos Ltd | Cosmos Ltd |
| Glucowell-Met | 50mg/500mg | Tablet | 30’s | Cosmos Ltd | Cosmos Ltd |
| Glucowell-Met | 50mg/850mg | Tablet | 28’s | Cosmos Ltd | Cosmos Ltd |
| Vigliptin-M | 50mg/850mg | Tablet | 30’s | Dawa Ltd | Dawa Ltd |
| Vigliptin-M | 50mg/500mg | Tablet | 30’s | Dawa Ltd | Dawa Ltd |
| Vigliptin-M | 50mg/1g | Tablet | 30’s | Dawa Ltd | Dawa Ltd |
| Vildamet | 50mg/1g | Tablet | 30’s | Innocia Lifesciences | Wessex Pharma |
| Vildamet | 50mg/500mg | Tablet | 30’s | Innocia Lifesciences | Wessex Pharma |
| Vildamet | 50mg/850mg | Tablet | 30’s | Innocia Lifesciences | Wessex Pharma |