• Type II DM:
    • PO 1-2 tabs OD
  • Tablet:
    • 2.5mg/1000mg
    • 5mg/1000mg
  • To be taken with evening meal

Saxagliptin: DPP-4 inhibitor; it inhibits dipeptidyl peptidase-4, slowing incretin metabolism, increasing insulin synthesis/release and decreasing glucagon levels

Metformin: Metformin: Biguanide; it delays the absorption of glucose from the GI tract and increase insulin sensitivity in the muscle thereby improving peripheral glucose uptake and utilization in cells.

  • Diarrhea
  • Nausea
  • Vomiting
  • Flatulence
  • Asthenia
  • URI
  • Indigestion
  • UTI
  • Headache
  • Vitamin B12 deficiency
  • Hypoglycemia
  • Abdominal discomfort
  • Abdominal pain
  • Peripheral edema
  • Anorexia
  • Renal impairment
  • Gastroenteritis
  • Hypersensitivity reaction
  • Metallic taste
  • Ovulation induction
  • Hypersensitivity to class/components
  • eGFR <30
  • eGFR 30-45 (treatment initiation use)
  • Type I DM
  • Metabolic acidosis
  • Diabetic ketoacidosis
  • Lactic acidosis
  • Hypoxemia
  • Dehydration
  • Sepsis
  • Surgery
  • Hepatic disease

WARNING

  • Lactic acidosis: post-marketing cases of hypothermia, hypotension, resistant bradyarrhythmias and death

None restricted

                          Drug Status

Availability Prescription only
Pregnancy Weigh risk vs benefit
Breastfeeding Not recommended
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Kombiglyze XR 5mg/1g Tablet 30’s AstraZeneca AstraZeneca
Kombiglyze XR 2.5mg/1g Tablet 60’s AstraZeneca AstraZeneca