- Type II DM:
- PO 1-2 tabs OD
- Tablet:
- 2.5mg/1000mg
- 5mg/1000mg
- To be taken with evening meal
Saxagliptin: DPP-4 inhibitor; it inhibits dipeptidyl peptidase-4, slowing incretin metabolism, increasing insulin synthesis/release and decreasing glucagon levels
Metformin: Metformin: Biguanide; it delays the absorption of glucose from the GI tract and increase insulin sensitivity in the muscle thereby improving peripheral glucose uptake and utilization in cells.
- Diarrhea
- Nausea
- Vomiting
- Flatulence
- Asthenia
- URI
- Indigestion
- UTI
- Headache
- Vitamin B12 deficiency
- Hypoglycemia
- Abdominal discomfort
- Abdominal pain
- Peripheral edema
- Anorexia
- Renal impairment
- Gastroenteritis
- Hypersensitivity reaction
- Metallic taste
- Ovulation induction
- Hypersensitivity to class/components
- eGFR <30
- eGFR 30-45 (treatment initiation use)
- Type I DM
- Metabolic acidosis
- Diabetic ketoacidosis
- Lactic acidosis
- Hypoxemia
- Dehydration
- Sepsis
- Surgery
- Hepatic disease
WARNING
- Lactic acidosis: post-marketing cases of hypothermia, hypotension, resistant bradyarrhythmias and death
None restricted
Drug Status
Availability | Prescription only |
Pregnancy | Weigh risk vs benefit |
Breastfeeding | Not recommended |
Schedule | Not controlled |
BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
---|---|---|---|---|---|
Kombiglyze XR | 5mg/1g | Tablet | 30’s | AstraZeneca | AstraZeneca |
Kombiglyze XR | 2.5mg/1g | Tablet | 60’s | AstraZeneca | AstraZeneca |