• Type II DM:
    • Initially PO 1 tab OD/BD
    • Max: 2550mg/45mg/day
  • Tablet:
    • 500mg/15mg
    • 850mg/15mg
  • Taken with meals
  • Hold treatment for surgery if restricting food/fluid

Pioglitazone: Thiazolidinedione

Metformin: Biguanide

  • URI
  • Edema
  • Diarrhea
  • Headache
  • Weight gain
  • Nausea
  • Vomiting
  • Flatulence
  • Asthenia
  • Indigestion
  • Vitamin B12 deficiency
  • Abdominal discomfort
  • Anorexia
  • Metallic taste
  • Rash
  • Myalgia
  • Fluid retention
  • Dilutional anemia
  • Ovulation induction
  • Hypersensitivity to components
  • Severe renal disease: eGFR <30 ml/min/1.73 m²
  • Acute or chronic metabolic acidosis, including DKA with or without coma
  • NYHA Class III or IV heart failure
  • peds pts
  • eGFR <30
  • eGFR 30-45 (treatment initiation use)
  • Hepatic disease
  • Type 1 DM
  • Lactic acidosis
  • Hypoxemia
  • Dehydration
  • Sepsis
  • Surgery
  • Active bladder cancer

WARNING

  • Thiazolidinediones cause or exacerbate congestive heart failure
  • Post-marketing cases of hypothermia, hypotension, resistant bradyarrhythmias and death have been reported

None restricted

                          Drug Status

Availability Prescription only
Pregnancy Category B3; Contraindicated
Breastfeeding Contraindicated
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Pioday M 500mg/15mg Tablet 30’s Galaxy Pharma Galaxy Pharma