- Type II DM:
- Initially PO 1 tab OD/BD
- Max: 2550mg/45mg/day
- Tablet:
- 500mg/15mg
- 850mg/15mg
- Taken with meals
- Hold treatment for surgery if restricting food/fluid
Pioglitazone: Thiazolidinedione
Metformin: Biguanide
- URI
- Edema
- Diarrhea
- Headache
- Weight gain
- Nausea
- Vomiting
- Flatulence
- Asthenia
- Indigestion
- Vitamin B12 deficiency
- Abdominal discomfort
- Anorexia
- Metallic taste
- Rash
- Myalgia
- Fluid retention
- Dilutional anemia
- Ovulation induction
- Hypersensitivity to components
- Severe renal disease: eGFR <30 ml/min/1.73 m²
- Acute or chronic metabolic acidosis, including DKA with or without coma
- NYHA Class III or IV heart failure
- peds pts
- eGFR <30
- eGFR 30-45 (treatment initiation use)
- Hepatic disease
- Type 1 DM
- Lactic acidosis
- Hypoxemia
- Dehydration
- Sepsis
- Surgery
- Active bladder cancer
WARNING
- Thiazolidinediones cause or exacerbate congestive heart failure
- Post-marketing cases of hypothermia, hypotension, resistant bradyarrhythmias and death have been reported
None restricted
Drug Status
Availability | Prescription only |
Pregnancy | Category B3; Contraindicated |
Breastfeeding | Contraindicated |
Schedule | Not controlled |
BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
---|---|---|---|---|---|
Pioday M | 500mg/15mg | Tablet | 30’s | Galaxy Pharma | Galaxy Pharma |