• Type 2 DM:
    • Initially 15-30mg OD with meals
    • Dose increased by 15mg to a max: 45mg
  • Tablet:
    • 15mg
    • 30mg
  • To be taken with meals

Thiazolidinedione

It increases insulin sensitivity and decreases hepatic gluconeogenesis

  • URI
  • Headache
  • Myalgia
  • Weight gain
  • Edema
  • Fluid retention
  • Flatulence
  • Dilutional anemia
  • Ovulation induction
  • Hypersensitivity to pioglitazone
  • Diabetic ketoacidosis
  • Moderate-severe hepatic impairment (ALT >2.5x ULN)
  • CHF (NYHA class III, IV)
  • Symptomatic CHF
  • Active bladder cancer
  • Type 1 DM
  • Pediatric patients

WARNING

Thiazolidinediones cause or exacerbate congestive heart failure

None restricted

                          Drug Status

Availability Prescription only
Pregnancy Category B3; Contraindicated
Breastfeeding Not recommended
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Actodeal 15mg Tablet 30’s Biodeal Labs Biodeal Labs
Actodeal 30mg Tablet 30’s Biodeal Labs Biodeal Labs
Pioday 15mg Tablet 30’s Galaxy Pharma Galaxy Pharma
Pioday 30mg Tablet 30’s Galaxy Pharma Galaxy Pharma
Piogluc 15mg Tablet 28’s Cosmos Ltd Cosmos Ltd
Piogluc 30mg Tablet 28’s Cosmos Ltd Cosmos Ltd