• Type 2 DM in patients inadequately controlled on diet, exercise, and monotherapy with either glimepiride or metformin:
    • Initial dose: PO 1mg/500mg taken with the largest meal.
    • Maintenance dose: Increases should be made in increments of 1mg/500mg per day, with at least one to two weeks between titrations.
    • Max: 8mg/2000mg

Tablet:

  • 1mg/500mg
  • 2mg/500mg
  • 2mg/1000mg
  • Take orally with meals to reduce GI  side effects (metformin) and the risk of hypoglycemia (glimepiride).
  • Regular monitoring of blood glucose levels is essential, especially during dosage adjustment.
  • Avoid excessive alcohol intake, as it may increase the risk of lactic acidosis (metformin).
  • Glimepiride (Sulfonylurea): It stimulates pancreatic beta cells to secrete insulin, thereby reducing blood glucose levels.
  • Metformin (Biguanide): It decreases hepatic glucose production, reduces intestinal glucose absorption and improves insulin sensitivity.
  • Hypoglycemia
  • Dizziness
  • Headache
  • GI disturbances (e.g. nausea, diarrhoea)
  • Metallic taste
  • Risk of lactic acidosis
  • Severe renal impairment
  • Hypersensitivity to glimepiride, metformin or any of the formulation’s components.
  • Diabetic ketoacidosis
  • Type 1 DM
  • Rifampicin
  • Trimethoprim
  • Verapamil
  • Cimetidine
  • Dolutegravir
  • Ranolazine
  • Vandetanib
  • Crizotinib
  • Olaparib
  • Fluconazole
  • Miconazole
  • Acetazolamide
  • Insulin
  • Phenytoin

                                   Drug Status

Availability Prescription only
Pregnancy Contraindicated
Breastfeeding Contraindicated
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Amaryl M 2mg/500mg Tablet 30’s Sanofi-Aventis Ressourcethica Kenya
Amaryl M SR 2mg/500mg Tablet 30’s Sanofi-Aventis Ressourcethica Kenya
Diapride Plus 1mg/500mg Tablet 30’s Micro Labs Micro Labs
Diapride Plus 2 2mg/500mg Tablet 30’s Micro Labs Micro Labs
Gemer 1mg/500mg Tablet 50’s Sun Pharma Sun Pharma
Gemer 2mg/500mg Tablet 50’s Sun Pharma Sun Pharma
Glimadien 1 1mg/500mg Tablet 30’s Wockhardt Ltd Pharma Specialities
Glimadien 2 2mg/500mg Tablet 30’s Wockhardt Ltd Pharma Specialities
Glisen MF 1mg/500mg Tablet 30’s Alembic Pharma Europa Healthcare
Glisen MF 2mg/500mg Tablet 30’s Alembic Pharma Europa Healthcare
Glisen MF 1 1mg/500mg Tablet 30’s Alembic Pharma Europa Healthcare
Glisen MF 2 2mg/500mg Tablet 30’s Alembic Pharma Europa Healthcare
Glymet 1mg/500mg Tablet 100’s Lincoln Pharma C/O Medox Pharma Medox Pharma
Glymet 2mg/500mg Tablet 100’s Lincoln Pharma C/O Medox Pharma Medox Pharma
Glypin-Met 2mg/500mg Tablet 30’s Cosmos Ltd Cosmos Ltd
Orinase-Met 1mg/500mg Tablet 30’s CCL Pharma Harley’s Ltd
Orinase-Met 2mg/500mg Tablet 30’s CCL Pharma Harley’s Ltd
Perglim M 1 1mg/500mg Tablet 30’s Kulal International Mega Lifesciences
Perglim M 2 2mg/500mg Tablet 30’s Kulal International Mega Lifesciences
Ziglim 1M 1mg/500mg Tablet 28’s Laboratory & Allied Laboratory & Allied
Ziglim 2M 2mg/500mg Tablet 28’s Laboratory & Allied Laboratory & Allied