- Type 2 DM
- MR: PO 30-120mg OD
- CR: Initially 60mg OD; can be increased by 30mg every 2 weeks. Max 120mg
- Non-controlled: Initially 40-320mg OD/BD. Max 320mg daily.
Tablet:
- 30mg
- 60mg
- 80mg
To be taken with breakfast.
2nd generation sulfonylurea.
It binds to the β cell sulfonyl urea receptor (SUR1) thereby blocking the ATP-sensitive potassium channels consequently decreasing potassium efflux and depolarization of beta cells of the pancreas. This causes the opening of voltage-dependent calcium channels in the beta cells resulting in calmodulin activation and the consequent exocytosis of insulin-containing secretory granules.
- Indigestion
- Nausea
- Constipation
- Diarrhoea
- Headache
- Sweating
- Weight increase
- Hypersensitivity to compound/class
- Diabetic ketoacidosis
- Diabetic glaucoma
- Severe hepatic or renal failure
- Porphyria
- Breastfeeding
- Type 1 DM
- Aspirin
Drug Status
Availability | Prescription only |
Pregnancy | Category C |
Breastfeeding | Contraindicated |
Schedule | Not controlled |
BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
---|---|---|---|---|---|
Diagluc | 80mg | Tablet | 28’s | Cosmos Ltd | Cosmos Ltd |
Diamicron MR | 30mg | Tablet | 30’s | Les Laboratoires | Harley’s Ltd |
Diamicron MR | 60mg | Tablet | 30’s | Les Laboratoires | Harley’s Ltd |
Diapro | 80mg | Tablet | 50’s | Beximco Pharma | Madawa Pharma |
Gliclazide | 30mg | Tablet | 60’s | Lek Pharma | Sandoz GMBH |
Glizid MR | 30mg | Tablet | 100’s | Panacea Biotec | Europa Healthcare |
Glycinorm MR | 30mg | Tablet | 30’s | IPCA Labs | Sai Pharma |
Melanov | 80mg | Tablet | 30’s | Micro Labs | Micro Labs |
Melanov MR | 60mg | Tablet | 30’s | Micro Labs | Micro Labs |
Oziclide MR | 60mg | Tablet | 30’s | Sun Pharma | Sun Pharma |