- Management of Type II DM:
- Initial dose: 2.5mg with breakfast.
- Adjusted every 1 week according to patient response by 2.5mgupto 15mg daily.
Tablet: 5mg
Doses above 10mg given in 2 divided doses.
Best taken in the morning before breakfast.
Second generation sulfonylurea.
It works by binding to ATP-sensitive potassium channels and inhibiting them in pancreatic beta cells. This causes depolarization of the cell membrane and opening of the voltage-dependent calcium channels. There is increase in intracellular calcium in the pancreatic beta cells and consequent stimulation of insulin release.
- GI disturbances such as nausea, vomiting, heartburn, anorexia, diarrhoea.
- Increased appetite
- Weight gain
- Hypoglycaemia
- Headache
- Dizziness
- Oedema
- Hyponatremia
- Photosensitivity
- Hypersensitivity to components
- Type 1 DM
- Diabetic ketoacidosis
- Severe infection/inflammation
- Trauma
- Impaired renal or hepatic function
- Elderly
- Malnourished patients
- Adrenal or pituitary insufficiency
- Bosentan
- Glipizide
- Ethanol
Drug Status
| Availability | Prescription only |
| Pregnancy | Category C; Contraindicated |
| Breastfeeding | Contraindicated |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Betanase | 5mg | Tablet | 30’s | Cadila Healthcare | Cadila Healthcare |
| Bioglibe | 5mg | Tablet | 100’s | Biodeal Labs | Biodeal Labs |
| Daonil | 5mg | Tablet | 30’s | Sanofi-Aventis | Sanofi-Aventis |
| Dicon | 5mg | Tablet | 100’s | Jayson Pharma | Jayson Pharma |
| Glibetics | 5mg | Tablet | 30’s | Harley’s Ltd | Harley’s Ltd |
| Gliboral | 5mg | Tablet | 60’s | Laboratori Guidotti | Phillips Therapeutics |
| Glimide | 5mg | Tablet | 100’s | Laboratory & Allied | Laboratory & Allied |
| Melix | 5mg | Tablet | 100’s | Lagap SA | Lagap SA |
| Nogluc | 5mg | Tablet | 28’s; 112’s | Cosmos Ltd | Cosmos Ltd |