• Type 2 DM:
    • Initially PO 50mg/ 500mg OR  50mg/ 1000mg BD
    • Max 300mg/2000mg
  • Tablet:
    • 50mg/ 500mg
    • 50mg/ 1000mg
    • 150mg/ 500mg
    • 150mg/ 1000mg
  • Take orally twice daily with meals to minimize gastrointestinal side effects from metformin.
  • Ensure adequate hydration to prevent dehydration due to the diuretic effect of canagliflozin.
  • Canagliflozin (SGLT2 Inhibitor): It reduces glucose reabsorption in the kidneys, leading to increased glucose excretion in urine and lowering blood glucose levels.
  • Metformin (Biguanide): It reduces hepatic glucose production, decreases intestinal glucose absorption, and improves insulin sensitivity.
  • Increased urination
  • UTIs
  • Genital infections
  • Dehydration
  • GI disturbances (e.g., nausea, diarrhea, abdominal discomfort)
  • Risk of lactic acidosis
  • Severe renal impairment
  • Hypersensitivity to components
  • Diabetic ketoacidosis
  • Hydrochlorothiazide
  • Phenobarbital
  • Phenytoin
  • Carbamazepine
  • Ritonavir
  • Efavirenz
  • Rifampin
  • Cholestyramine
  • Digoxin
  • Digitoxin
  • Salbutamol
  • Terbutaline
  • Ibuprofen
  • Celecoxib
  • Cimetidine
  • Dabigatran

                                   Drug Status

Availability Prescription only
Pregnancy Contraindicated
Breastfeeding Contraindicated
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Vokanamet 150mg/1g Tablet 60’s Phillips Therapeutics Janssen Ortho LLC