• Acute MI :
    • <60 kg: IV 30mg
    • 60-70 kg: IV 35mg
    • 70-80 kg:  IV 40mg
    • 80-90 kg: IV 45mg
    • >90 kg: IV 50mg
  • Acute ischaemic stroke (Off-label):
    • IV 0.25mg/kg *1
    • Start immediately within 4.5 hours of symptoms onset
    • For patients eligible for mechanical thrombectomy

Injection: 50mg

  • Use immediately or may be refrigerated up to 8 hours

Thrombolytics

It binds to fibrin and converts tissue plasminogen to plasmin, promoting fibrinolysis

  • Bleeding
  • Hypersensitivity to class/components
  • Active internal bleeding
  • Stroke history
  • Intracranial or intraspinal surgery or trauma within prior 2 months
  • Intracranial aneurysm
  • Intracranial AVM
  • Intracranial neoplasm
  • Coagulation disorder
  • Severe uncontrolled hypertension
  • Defibrotide
  • Mifepristone

                          Drug Status

Availability Prescription only
Pregnancy Category C
Breastfeeding Can be used
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Elaxim 52.5mg Injection 1’s Emcure Pharma Lazor Pharma
Metalyse 10,000 U (50mg) Injection 1’s Boehringer Ingelheim Surgipharm Ltd