- Complicated intra-abdominal infections:
- Initially 100mg IV infusion, then 50mg IV infusion BD *5-14 days
- Initially 100mg IV infusion, then 50mg IV infusion BD *5-14 days
- Complicated skin infections:
- Initially 100mg IV infusion, then 50mg IV infusion BD *5-14 days
- Initially 100mg IV infusion, then 50mg IV infusion BD *5-14 days
- Community-acquired pneumonia:
- Initially 100mg IV infusion, then 50mg IV infusion BD *5-14 days
Injection: 50mg
Infuse over 30-60 min
Glycylcycline antibiotic that is structurally similar to tetracycline antibiotics
It inhibits bacterial protein translation by binding to 30S ribosomal subunit and blocks entry of amino-acyl tRNA molecules in ribosome A site.
- Nausea
- Vomiting
- Diarrhea
- Infection
- Abdominal pain
- Headache
- Anemia
- Hypoproteinemia
- Asthenia
- Increased BUN
- Dizziness
- Abnormal healing
- Hyperamylasemia
- Elevated LFTs
- Rash
- Abscess
- Dyspepsia
- Hyponatremia
- Photosensitivity
- Enamel hypoplasia
- Hypersensitivity to components
- Hypersensitivity to tetracyclines
- Pregnancy
- Patients < 8 years
- Hospital-acquired pneumonia use
- Ventilator-associated pneumonia use
- Diabetic foot infection use
WARNING
Increased mortality in patients treated with tigecycline than comparators in clinical trial meta-analysis
None restricted
Drug Status
| Availability | Prescription only |
| Pregnancy | Category D |
| Breastfeeding | Contraindicated |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Tiggy | 50mg/5mL | Injection | 1’s | Oriana Limited | Glenmark Pharma |
| Tygacil | 50mg | Injection | 10’s | Pfizer Labs | Pfizer Labs |