• Complicated skin and soft tissue infections:
    • Loading dose: IV/IM 6mg/kg BD *3 doses.
    • Maintenance dose: IV/IM 6mg/kg OD
  • Complicated urinary tract infections:
    • Loading dose: IV/IM 6mg/kg BD *3 doses.
    • Maintenance dose: IV/IM 6mg/kg OD
  • Complicated lower respiratory tract infections:
    • Loading dose: IV/IM 6mg/kg BD *3 doses.
    • Maintenance dose: IV/IM 6mg/kg OD
  • Bone and joint infections:
    • Loading dose: IV/IM 12mg/kg BD *3-5 doses
    • Maintenance dose: IV/IM 12mg/kg OD
  • Endocarditis:
    • Loading dose: IV/IM 12mg/kg BD *3-5 doses
    • Maintenance dose: IV/IM 12mg/kg OD
  • Surgical prophylaxis (Off-label):
    • IV 400mg 30 minutes before procedure
    • Open fractures: IV 800mg by intravenous infusion 30 minutes before skeletal stabilisation and definitive soft tissue closure
  • Peritonitis related to continuous ambulatory peritoneal dialysis:
    • Loading dose: IV 6mg/kg as a single dose
    • Dose: 20mg/L is administered in the bag of the dialysis solution in the 1st week, 20mg/L per alternate bag in the 2nd week and 20mg/L in the overnight dwell bag only during the 3rd
  • Clostridium difficile-associated diarrhoea:
    • PO 100mg-200mg BD *7 to 14 days.

Children dosing:

  • 2 months-12 yrs:
    • Loading dose: IV 10mg/kg BD *3 doses
    • Maintenance dose: IV 6mg/kg to 10mg/kg as a single dose each day
  • < 2 months:
    • Loading dose: IV 16mg/kg as a single dose *1/7 over 30 minutes
    • Maintenance dose: IV 8mg/kg OD over 30 minutes
  • Injection:
    • 200mg
    • 400mg
  • The reconstituted injection may be administered intravenously, intramuscularly or orally.
  • If given IV, teicoplanin may be administered as an IV bolus injection over 3-5 minutes or as an IV infusion over 30 minutes.
  • IV route is preferable in children.
  • Only IV infusion must be used in neonates.

Glycopeptide antibiotic

Binds to the d-alanyl-d-alanine moiety and sequestration of the lipid II substrate, resulting in inhibition of bacterial peptidoglycan synthesis thereby inhibiting bacterial cell wall synthesis

  • Rashes
  • Fever
  • Local pain and redness at the injection site
  • Dizziness
  • Changes in the results of blood and liver tests
  • Abnormalities (increases/decreases) in the number of white blood cells and platelets
  • Thrombocytopenia
  • Red man syndrome
  • Kidney problems
  • Amphotericin B
  • Ciclosporin
  • Cisplatin
  • Furosemide
  • Etacrynic acid
  • Alcohol

                                   Drug Status

Availability Prescription only
Pregnancy Weigh risk vs benefit
Breastfeeding Weigh risk vs benefit
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Targocid 200mg Injection 1’s Sanofi-Aventis Ressourcethica Kenya
Targocid 400mg Injection 1’s Sanofi-Aventis Ressourcethica Kenya
Ticplat 200mg Injection 1’s Gufic Stridden Biopharma Europa Healthcare
Ticplat 400mg Injection 1’s Gufic Stridden Biopharma Europa Healthcare