• Intra-abdominal infection (appendicitis/peritonitis):
    • Adults: IV 3.375g every 6 hours *4-7 days
    • 2-9 month old: IV 270mg/kg/day divided TDS *4-7 days
    • 9 months and older (<40 kg): IV 337.5mg/kg/day divided TDS *4-7 days
    • 9 months and older (<40 kg): IV 3.375g every 6 hours *4-7 days
  • Gynecologic infections (PID or postpartum endometriosis):
    • IV 3.375g every 6 hours *7-10 days
  • Skin & soft tissue infections:
    • IV 3.375g every 6 hours *7-10 days
  • Community-acquired pneumonia:
    • IV 4.5g every 6 hours*1/52
  • Hospital-acquired pneumonia:
    • 2-9 month old: IV 360 g/kg/day divided every 6 hours*7-14 days
    • 9 months and older (<40 kg): IV 450g/kg/day divided every 6 hours *7-14 days
    • 9 months and older (<40 kg): IV 4.5g every 6 hours *7-14 days

Renal Modifications:

  • If usual dose 3.375g every 6 hours:
    • CrCl 20-40 mL/min: 25g every 6 hours
    • CrCl <20 mL/min: 2g TDS
    • Hemodialysis: 25g BD
      • Give 0.75g as supplement after dialysis if next maintenance dose not due right after dialysis
    • Peritoneal dialysis: 25gBD
      • No supplement
  • If usual dose 4.5g every 6 hours:
    • CrCl 20-40 mL/min: 375g every 6 hours
    • CrCl <20 mL/min: 25g every 6 hours
    • Hemodialysis: 25g TDS
      • Give 0.75g as supplement after dialysis if next maintenance dose not due right after dialysis
    • PD: 25g TDS
      • No supplement

Injection:

  • 4ooomg/500mg

None significant

Piperacillin: Penicillin; it binds to peptidoglycan, inhibiting cell wall synthesis

Tazobactam: Beta-lactamase inhibitor; it inhibits beta-lactamases thereby preventing beta-lactam degradation

  • Diarrhea
  • Headache
  • Constipation
  • Nausea
  • Insomnia
  • Rash
  • Vomiting
  • Dyspepsia
  • Pruritus
  • Fever
  • Agitation
  • Electrolyte abnormalities
  • Elevated LFTs
  • Hypersensitivity to class or components
  • Hypersensitivity to beta lactams
  • Enoxaparin
  • Fondaparinux
  • Methotrexate
  • BCG live vaccine
  • Heparin

                          Drug Status

Availability Prescription only
Pregnancy Safe to use
Breastfeeding Safe to use
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Aurotaz-P 4000mg/500mg Injection 1’s Aurobindo Pharma Aurobindo Pharma
Injpip TZ 4000mg/500mg Injection 1’s Surgilinks Ltd C/O Injectionect Care Surgilinks Ltd
Inno-Zopip 4000mg/500mg Injection 1’s Innocia Lifesciences Wessex Pharma
Piptaz 4000mg/500mg Injection 1’s Zawadi Healthcare Zawadi Healthcare
Piptazo 4000mg/500mg Injection 1’s Sandoz GMBH Novartis Kenya
Pipzo 4000mg/500mg Injection 1’s Alkem Labs Pharmacor Ltd
Pizomark 4000mg/500mg Injection 1’s Marksans Pharma Sai Pharma
Tazocin EF 4000mg/500mg Injection 1’s Pfizer Labs Pfizer Labs