- Amoebiasis:
- Adults : 500mg BD *5-7 days
- Children: 25mg/kg OD *5-7 days
- Amoebic Dysentery:
- Adults: 5 g OD *3/7
- Children: 40mg/kg OD *3/7
- Prophylaxis of susceptible anaerobic infections in dental and GI surgery:
- Adult: 500mg BD *5-7 days
- Giardiasis:
- Adults: 5 g OD * 1-2 days
- Children: 40mg/kg OD *2/7
- Trichomoniasis
- Adults: 5g OD OR 500mg BD *5/7.
- Bacterial Vaginosis
- Adults: 5g OD OR 500mg BD *5/7.
- Anaerobic Bacterial Infection
- Adults: 500mg BD * 5 -10 days
- Children: 10mg/kg BD
- Tablet: 500mg
- Suspension: 125mg/5ml
- Can be taken with or soon after food.
- For trichomoniasis, the sexual partners should be treated simultaneously.
5-nitroimidazole.
It is selective for anaerobic bacteria due to their ability to intracellularly reduce imidazole which covalently binds to DNA, disrupt its helical structure thereby inhibiting nucleic acid synthesis.
- Somnolence
- Headache
- GI disturbances
- Dizziness
- Drowsiness
- Tremor
- Rigidity
- Seizures
- Peripheral neuropathy
- Taste disturbances
- Skin reactions
- Hypersensitivity to components/class
- Neurological disease
- First trimester pregnancy
CAUTION:
- History of epilepsy
- Multiple sclerosis
- Hepatic or kidney damage
- Oral anticoagulants
- Vecuronium bromide
Drug Status
| Availability | Prescription or OTC by Pharmacist |
| Pregnancy | Use with caution |
| Breastfeeding | Use with caution |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Dazolic | 500mg | Tablet | 100’s | Sun Pharma | Sun Pharma |
| Diarobic | 500mg | Tablet | 10’s | BelEa Pharmacy | Discount Healthcare |
| Giro | 500mg | Tablet | 100’s | Panacea Biotec | Europa Healthcare |
| Granid | 500mg | Tablet | 10’s | Gracure Pharma | Medisel Kenya |
| Granid | 125mg/5mL | Suspension | 30mL | Gracure Pharma | Medisel Kenya |
| Ordazole | 500mg | Tablet | 10’s | Meyer Organic | Galaxy Pharma |
| Orgyl | 500mg | Tablet | 10’s | Kusum Healthcare | Zawadi Healthcare |
| Ornilor | 500mg | Tablet | 30’s | Lords Healthcare | Lords Healthcare |
| Ornimed | 500mg | Suspension | 30mL | Global Pharma | Medistar Pharma |
| Ornitab | 500mg | Tablet | 10’s | Galaxy Pharma | Galaxy Pharma |