- Surgical prophylaxis and surgical wound infections
- Gynecological infections including prophylaxis in gynecological surgeries.
- Intra-abdominal infections & diarrhea of mixed bacterial & protozoal origin.
- Severe intestinal & hepatic amoebiasis.
- Giardiasis
- Trichomoniasis
- Bacterial vaginosis
- Gonorrhea
- Peritonitis
- Respiratory tract infections e.g. lung abscess
- Dental infections
- Cellulitis
- Gangrene
- Diabetic & decubitus ulcers
1 tab BD * 5/7
Can be extended for 10-14 days.
200mg/500mg
Effects can be enhanced by alcohol
Ofloxacin is a fluorinated quinolone antibacterial agent against gram positive organisms. It interferes with bacterial DNA synthesis by inhibiting topoisomerase II & IV, causing bacterial cell death.
Ornidazole, a nitroimidazole, has activity against protozoa and anaerobic bacteria. It’s selective for anaerobic bacteria due to the ability to intracellularly reduce imidazole which covalently binds to DNA, disrupt its helical structure thereby inhibiting nuclei acid synthesis. Has a longer half-life than metronidazole.
- Hypersensitivity reactions
- CNS disturbances such as dizziness, vertigo, hallucinations and seizures
- GI disturbances
- Blood dyscrasias
- Visual and sensory disturbances.
- Pregnancy and lactation
- History of epilepsy
- Vertigo
- Ataxia
- Mental confusion
- Children
- Hypersensitivity reactions.
- Antacids
- Sucralfate or iron preparations
- Warfarin
- Theophylline
- Isoniazid
- Phenothiazines
- Tricyclic depressants
- Glibenclamide
- Alcohol.
Drug Status
| Availability | Prescription or OTC by pharmacist |
| Pregnancy | Category B3; Contraindicated |
| Breastfeeding | Contraindicated |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Agiflo-OZ | 200mg/500mg | Tablet | 50’s | Agio Pharma | Agio Pharma |
| Combizol | 200mg/500mg | Tablet | 10’s | Zest Pharma | Synermed Pharma |
| DTO | 200mg/500mg | Tablet | 10’s | Twokay Chemicals | Twokay Chemicals |
| Immobiotic | 200mg/500mg | Tablet | 10’s | Biopharma Ltd | Biopharma Ltd |
| Lasoflox-O | 200mg/500mg | Tablet | 10’s | Laso Healthcare | Simba Pharma |
| Loobid (+ Lactic Acid Bacillus) | 200mg/500mg/60 million spores | Tablet | 10’s | Cachet Pharma | Pharma Specialities |
| O2 | 200mg/500mg | Tablet | 10’s | Medley Pharma | Medisel Kenya |
| Of-Orni | 200mg/500mg | Tablet | 10’s | Brilliant Lifesciences | Starbiotech Ltd |
| Ofcian-O | 200mg/500mg | Tablet | 10’s | Cian Health Care | Cian Health Care |
| Oflodaz | 200mg/500mg | Tablet | 10’s | Highchem Marketing | Highchem Marketing |
| Oflonida | 200mg/500mg | Tablet | 10’s | National Pharmacy | National Pharmacy |
| Ofzo | 200mg/500mg | Tablet | 30’s | Comed Chemicals | Ripple Pharma |
| Ojen OZ | 200mg/500mg | Tablet | 10’s | Jenburkt Pharma | Unisel Ltd |
| Ooz | 200mg/500mg | Tablet | 10’s | PSM Pharma | PSM Pharma |
| Orav-OZ | 200mg/500mg | Tablet | 10’s | Ravian Life Sciences | Pharma Branding |
| Ornifloxin | 200mg/500mg | Tablet | 10’s | Galaxy Pharma | Galaxy Pharma |
| Ornilox | 200mg/500mg | Tablet | 10’s | Micro Labs | Micro Labs |
| Polymic | 200mg/500mg | Tablet | 10’s | Kusum Healthcare | Zawadi Healthcare |
| Saraoflo-OZ | 200mg/500mg | Tablet | 10’s | Krishna Chemists | Krishna Chemists |
| Xin-O | 200mg/500mg | Tablet | 10’s | Crown Healthcare | Crown Healthcare |
| Z-Oflox OZ | 200mg/500mg | Tablet | 10’s | Zawadi Healthcare | Zawadi Healthcare |
| Zoflox | 200mg/500mg | Tablet | 10’s | Dolopharma Healthcare | Dolopharma Healthcare |