• Community-acquired/hospital-acquired pneumonia:
    • Adults: PO/IV 600mg BD *1/52
    • <34 wk gestation, ≥7 days old: PO/IV 30mg/kg/day divided TDS *10-14 days
    • <34 wk gestation, <7 days old: PO/IV 20mg/kg/day divided BD *10-14 days
    • <12 years: PO/IV 30mg/kg/day divided TDS *10-14 days
  • Complicated skin & skin structure infections:
    • Adults: PO/IV 600mg BD *10-14 days
    • <12 years: PO/IV 10mg/kg TDS *10-14 days
    • ≥12 years: PO/IV 600mg BD *10-14 days
  • Uncomplicated skin & skin structure infections:
    • Adults: PO 400-600mg BD *10-14 days
    • <5 years: PO 10mg/kg TDS *10-14 days
    • 5-12 years: PO 10mg/kg TDS *10-14 days
    • >12 years: PO 600mg BD *10-14 days
  • Vancomycin-resistant enterococcal infections:
    • Adults: PO/IV 600mg BD *14-28 days
    • <12 years: PO/IV 10mg/kg TDS *14-28 days
    • ≥12 years: PO/IV 600mg BD *14-28 days
  • MRSA:
    • PO/IV 600mg BD *10-14 days
  • Endocarditis (Off-label):
    • PO/IV 600mg BD *>6 weeks
  • Systemic anthrax (Off-label):
    • IV 600mg BD for at least 2 weeks
    • Part of multi-drug regimen
  • Tablet:
    • 600mg
  • Suspension:
    • 100mg/5mL
  • Injection:
    • 600mg
  • Infusion should be administered over 30-120 min
  • Use reconstituted suspension within 21 days

Oxazolidinones

It binds to 50S ribosomal subunit, inhibiting protein synthesis

  • Diarrhea
  • Vomiting
  • Headache
  • Nausea
  • Anemia
  • Thrombocytopenia
  • Rash
  • Hypertension
  • Hypersensitivity to class/components
  • MAO inhibitor use within 14 days
  • High tyramine-containing food
  • Amoxapine
  • Apraclonidine
  • Armodafinil
  • Atomoxetine
  • Benzphetamine
  • Brimonidine
  • Buspirone
  • Caffeine
  • Carbamazepine
  • Cyproheptadine
  • Desvenlafaxine
  • Deutetrabenazine
  • Dexfenfluramine
  • Dexmethylphenidate
  • Dextroamphetamine
  • Diethylpropion
  • Dobutamine
  • Dopamine
  • Dosulepin
  • Ephedrine
  • Epinephrine
  • Fenfluramine
  • Fluoxetine
  • Isometheptene
  • Isoproterenol
  • Lisdexamfetamine
  • Lofepramine
  • Meperidine
  • Methamphetamine
  • Methylenedioxymethamphetamine
  • Methylphenidate
  • Midodrine
  • Modafinil
  • Norepinephrine
  • Ozanimod
  • Phendimetrazine
  • Phentermine
  • Phenylephrine
  • Phenylephrine po
  • Propylhexedrine
  • Pseudoephedrine
  • Safinamide
  • Serdexmethylphenidate/dexmethylphenidate
  • Solriamfetol
  • Tetrabenazine
  • Tyramine
  • Vortioxetine
  • Xylometazoline
  • Yohimbine

                          Drug Status

Availability Prescription only
Pregnancy Category C
Breastfeeding Weigh risk vs benefit
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Arlin 400mg Tablet 20’s Beximco Pharma Madawa Pharma
Arlin 0.2% w/v Injection 1’s Beximco Pharma Madawa Pharma
Bactolid 600mg Tablet 10’s Hetero Labs Unisel Ltd
Linzo 600mg Tablet 6’s Medisel Kenya Medisel Kenya
Lizolid 600mg Tablet 12’s Glenmark Pharma Glenmark Pharma
Lizolid 600mg Injection 300mL Glenmark Pharma Glenmark Pharma
Lizomac 600mg Tablet 20’s Macleods Pharma Macleods Pharma
Lizomed 600mg Tablet 4’s Aglowmed Ltd Sai Pharma
Lizomed 100mg/5mL Suspension 30mL Aglowmed Ltd Sai Pharma