- Community-acquired pneumonia:
- PO/IV 500 mg OD * 7-14 days OR 750 mg PO/IV OD * 5/7
- Nosocomial pneumonia:
- PO/IV 750 mg OD * 7-14 days
- Acute bacterial exacerbation of chronic bronchitis (reserved for patients who do not have other available treatment options)
- PO/IV 500 mg OD * ≥7 days
- Complicated UTI and acute pyelonephritis:
- PO/IV 250 mg OD * 10/7 OR 750 mg PO/IV OD * 5/7
- Uncomplicated UTI( reserved for patients who do not have other available treatment options):
- PO/IV 250 mg OD * 3/7
- Skin & soft tissue infections:
- Uncomplicated: PO/IV 500 mg OD * 7-10 days
- Complicated: PO/IV 750 mg OD * 7-14 days
- Chronic bacterial prostatitis:
- PO/IV 500 mg OD * 28/7
- Epididymitis (Off-label):
- PO 500 mg OD *10/7
Tablet:
- 250mg
- 500mg
- 750mg
Infusion:
- 500mg/100 mL
- Due to the risk of the serious side effects that generally outweigh the benefits for patients with acute bacterial sinusitis, acute exacerbation of chronic bronchitis and uncomplicated UTI, fluoroquinolones should be reserved for use in patients with these conditions who have no alternative treatment options.
- Can be administered without regard to food.
- Give by IV infusion only, not bolus. Rapid or bolus administration has been associated with hypotension and must be avoided.
- Infuse 250-500 mg over 60 minutes or 750 mg over 90 minutes.
Fluoroquinolone.
L-stereoisomer of parent compound Ofloxacin. D-isomer form is inactive.
It inhibits DNA gyrase (topoisomerase II) and topoisomerase IV activity necessary bacterial DNA synthesis. This in turn promotes breakage of DNA strand.
It has good monotherapy with extended coverage against Pseudomonas spp, as well as excellent activity against pneumococcus.
- Nausea
- Diarrhea
- Abdominal pain
- Headache
- Local irritation at site of injection
- Impaired taste and smell sensation
- Constipation
- Dyspepsia
- Dizziness
- Insomnia
- Skin rash
- Photosensitivity
- Blurred vision
- Psychotic reactions
- Hypersensitivity to fluoroquinolones
- Children < 18 years.
- History of tendon disorders related to quinolone use.
- Antacids
- NSAIDs
- Sucralfate
- Theophylline
- Zinc supplements
- Iron tablets
- Didanosine
- Fenbufen
Drug Status
| Availability | Prescription only |
| Pregnancy | Category B3; Contraindicated |
| Breastfeeding | Contraindicated |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Ablevox | 500mg | Injection | 100mL | Abacus Pharma | Abacus Pharma |
| Agilevo | 500mg | Tablet | 5’s | Agio Pharma | Phillips Healthcare |
| Agilevo | 750mg | Tablet | 50’s | Agio Pharma | Phillips Healthcare |
| Anflox | 750mg | Tablet | 10’s | Pro Med Pharma | Pro Med Pharma |
| Anflox | 500mg | Tablet | 10’s | Pro Med Pharma | Pro Med Pharma |
| Axalevo | 500mg | Injection | 100mL | Axa Parenterals | Axa Parenterals |
| C-Levo | 500mg | Tablet | 10’s | Crown Healthcare | Crown Healthcare |
| Conolevo | 500mg | Tablet | 10’s | Ratnamani Healthcare | Hasscon Pharma |
| Evo | 500mg | Tablet | 20’s | Beximco Pharma | Madawa Pharma |
| Evonex | 500mg | Tablet | 20’s | Jayson Pharma | Jayson Pharma |
| Flovanis | 500mg | Tablet | 10’s | Opsonin Pharma | Opsonin Pharma |
| Floxamed | 500mg | Tablet | 10’s | Nacc-Med Pharma | Nacc Med Pharma |
| Gen-Levo | 500mg | Injection | 100mL | Brookes Pharma | Harley’s Ltd |
| Gen-Levo | 250mg | Tablet | 10’s | Brookes Pharma | Crown Healthcare |
| Gen-Levo | 500mg | Tablet | 10’s | Brookes Pharma | Crown Healthcare |
| Glevonix | 500mg | Tablet | 10’s | Glenmark Pharma | Glenmark Pharma |
| Glevonix | 500mg | Injection | 100mL | Glenmark Pharma | Glenmark Pharma |
| Glevonix | 750mg | Tablet | 10’s | Glenmark Pharma | Glenmark Pharma |
| Lamiwin | 500mg | Injection | 100mL | Alembic Pharma | Europa Healthcare |
| Lamiwin | 500mg | Tablet | 100’s | Alembic Pharma | Europa Healthcare |
| L-Bac | 500mg | Tablet | 5’s | Popular Pharma | Omaera Pharma |
| L-Vxin | 500mg | Tablet | 10’s | Pharma Life Science | Pharma Life Science |
| Leeflox | 500mg | Tablet | 5’s | Centaur Pharma | Sai Pharma |
| Leflocin | 750mg | Injection | 100mL | Yuria Pharma | Harley’s Ltd |
| Leflocin | 500mg | Injection | 100mL | Yuria Pharma | Harley’s Ltd |
| Leflox | 750mg | Tablet | 10’s | Getz Pharma | Surgipharm Ltd |
| Leflox | 500mg | Injection | 100mL | Getz Pharma | Surgipharm Ltd |
| Lefloxin | 500mg | Tablet | 10’s | PSA International | Avacare Kenya |
| Levanix | 500mg | Tablet | 7’s | Neo Pharma | Pharma Specialities |
| Levin | 500mg | Tablet | 10’s | Hetero Labs | Unisel Ltd |
| Levo | 500mg | Tablet | 10’s | Ferozsons Labs C/O Surgilinks Ltd | Surgilinks Ltd |
| Levo-Denk | 250mg | Tablet | 10’s | Denk Pharma | Laborex Kenya |
| Levo-Denk | 500mg | Tablet | 10’s | Denk Pharma | Laborex Kenya |
| Levo-G | 500mg | Tablet | 10’s | Gracure Pharma | Medisel Kenya |
| Levo-G | 750mg | Tablet | 10’s | Medisel Kenya | Medisel Kenya |
| Levo-Q | 750mg | Tablet | 10’s | Universal Corporation | Universal Corporation |
| Levobact | 750mg | Tablet | 10’s | Micro Labs | Micro Labs |
| Levobact | 500mg | Tablet | 10’s | Micro Labs | Micro Labs |
| Levobact | 250mg | Tablet | 5’s | Micro Labs | Micro Labs |
| Levocil | 250mg | Tablet | 10’s | CCL Pharma | Harley’s Ltd |
| Levocil | 500mg | Tablet | 10’s | CCL Pharma | Harley’s Ltd |
| Levocil | 500mg | Injection | 100mL | CCL Pharma | Harley’s Ltd |
| Levocil | 500mg | Injection | 100mL | CCL Pharma | Harley’s Ltd |
| Levocil | 250mg | Tablet | 10’s | CCL Pharma | Harley’s Ltd |
| Levocin | 500mg | Injection | 100mL | Pt Sanbe Farma | Sai Pharma |
| Levocin | 500mg | Injection | 100mL | PT Sanbe Farma | Sai Pharma |
| Levoday | 500mg | Tablet | 10’s | Cadila Healthcare | Cadila Healthcare |
| Levodon | 500mg | Injection | 100mL | Cipla Ltd | Imperial Managed |
| Levoflacin | 500mg | Tablet | 10’s | Harley’s Ltd | Harley’s Ltd |
| Levoflacin | 250mg | Tablet | 10’s | Harley’s Ltd | Harley’s Ltd |
| Levogol | 500mg | Injection | 100mL | Zawadi Healthcare | Zawadi Healthcare |
| Levokop | 500mg | Tablet | 10’s | Kopran Ltd C/O. Surgilinks Ltd | Surgilinks Ltd |
| Levomac | 500mg | Tablet | 5’s | Macleods Pharma | Sai Pharma |
| Levomac | 500mg | Injection | 100mL | Macleods Pharma | Sai Pharma |
| Levomac | 750mg | Tablet | 10’s | Macleods Pharma | Sai Pharma |
| Levomac | 250mg | Tablet | 5’s | Macleods Pharma | Sai Pharma |
| Levomac | 500mg | Tablet | 5’s | Macleods Pharma | Sai Pharma |
| Levomac | 750mg | Tablet | 10’s | Macleods Pharma | Sai Pharma |
| Levomax | 500mg | Tablet | 10’s | Eskayef Ltd | Umoja Pharma |
| Levomax | 750mg | Tablet | 10’s | Eskayef Ltd | Umoja Pharma |
| Levomed | 250mg | Tablet | 10’s | Aglowmed Ltd | Sai Pharma |
| Levomed | 500mg | Tablet | 10’s | Aglowmed Ltd | Sai Pharma |
| Levopro | 500mg | Tablet | 10’s | PSM Pharma | PSM Pharma |
| Levostand | 500mg | Tablet | 10’s | Mankind Pharma | Pharma Specialities |
| Levotil | 500mg | Tablet | 10’s | Nextgen Pharma | Nextgen Pharma |
| Levotop | 500mg | Tablet | 10’s | Ajanta Pharma | Harley’s Ltd |
| Levox | 500mg | Tablet | 10’s | Lords Healthcare | Lords Healthcare |
| Levoxcin | 750mg | Tablet | 10’s | Dawa Ltd | Dawa Ltd |
| Levoxcin | 500mg | Tablet | 10’s | Dawa Ltd | Dawa Ltd |
| Levoz | 500mg | Tablet | 5’s | Shelys Pharma | Beta Healthcare |
| Levoz | 750mg | Tablet | 10’s | Shelys Pharma | Beta Healthcare |
| Livota | 500mg | Tablet | 10’s | Zawadi Healthcare | Zawadi Healthcare |
| Livota | 750mg | Tablet | 10’s | Zawadi Healthcare | Zawadi Healthcare |
| Loxamox | 500mg | Injection | 100mL | Pharma Jordan | Generics Africa |
| Loxamox | 500mg | Injection | 100mL | Pharma Jordan | Generics Africa |
| Mlevo | 500mg | Tablet | 10’s | National Pharmacy | National Pharmacy |
| MyDawa Levofloxacin | 750mg | Tablet | 10’s | MyDawa Trading | ION Kenya |
| MyDawa Levofloxacin | 500mg | Tablet | 10’s | Finecure Pharma | ION Kenya |
| Nirliv | 500mg | Injection | 100mL | Aculife Healthcare | Crown Healthcare |
| Oraflox | 500mg | Injection | 100mL | Cachet Pharma | Pharma Specialities |
| Quixin | 0.5% w/v | Eye Drops | 10mL | Helix Pharma | Globe Pharmacy |
| Safelevo | 500mg | Tablet | 10’s | MSN Labs | Simba Pharma |
| Safelevo | 750mg | Tablet | 5’s | MSN Labs | Simba Pharma |
| Safloxa | 750mg | Tablet | 10’s | Krishna Chemists | Krishna Chemists |
| Safloxa | 500mg | Tablet | 10’s | Krishna Chemists | Krishna Chemists |
| Spectrix | 500mg | Tablet | 10’s | Pharmevo | Harley’s Ltd |
| Tavanic | 500mg | Tablet | 5’s | Sanofi-Aventis | Ressourcethica Kenya |
| Tavanic IV | 5mg/mL | Injection | 100mL | Sanofi-Aventis | Ressourcethica Kenya |
| Tigeron | 750mg | Tablet | 5’s | Kusum Healthcare | Zawadi Healthcare |
| Utivanic | 500mg | Tablet | 10’s | Signature Healthcare | Signature Healthcare |
| Uvex | 500mg | Tablet | 10’s | Meyer Organics | Harley’s Ltd |
| Vofax | 500mg | Tablet | 10’s | Crown Healthcare | Crown Healthcare |
| Vofax Plus | 750mg | Tablet | 10’s | Crown Healthcare | Crown Healthcare |
| Welquine | 500mg | Injection | 100mL | Unosource Pharma | Unisel Ltd |
| Welquine | 500mg | Tablet | 10’s | Unosource Pharma | Unisel Ltd |
| Xolfovel | 500mg | Tablet | 10’s | Sandoz GMBH | Sandoz GMBH |
| Zolevox | 500mg | Tablet | 10’s | Innocia Lifesciences | Wessex Pharma |
| Zolevox | 750mg | Tablet | 10’s | Innocia Lifesciences | Wessex Pharma |