• Bacterial infections:
    • Adult: IV 500mg every 6 hours or 1g every 6-8 hours
    • Max 4g/day
  • Intra-abdominal infections:
    • Adult: IV 500mg every 6 hours or 1g every 6-8 hours
    • Max 4g/day
  • Uncomplicated UTI:
    • IV 500mg every 6 hours
  • Hospital-acquired or community-acquired pneumonia:
    • IV 500mg every 6 hours *1/52
  • Chemotherapy-induced febrile neutropenia (Off-label):
    • IV 500mg every 6 hours
    • Max 4g/day
  • Systemic anthrax:
    • IV 1g every 6 hours for at least 2 weeks
    • Max 4g/day
    • Not 1st-line agent
    • Part of multi-drug regimen
    • Switch to oral antibiotics for post-exposure prophylaxis if inhalational exposure

Injection: 500mg/500mg

  • Do not administer by IV push
  • If nausea or vomiting occurs during administration, reduce infusion rate

Imipenem: carbapenem; it binds to peptidoglycan, inhibiting cell wall synthesis

Cilastatin: Beta-lactam; inhibits renal dihydropeptidase I, preventing imipenem metabolism

  • Increased eosinophils
  • Increased LFTs
  • Seizures (peds patients)
  • Increased Cr
  • Platelet abnormalities
  • Diarrhea
  • Thrombophlebitis
  • Oliguria (peds patients)
  • Anuria (peds patients)
  • Rash
  • Nausea
  • Hypersensitivity to components/class

None restricted

                          Drug Status

Availability Prescription only
Pregnancy Category B3
Breastfeeding Use with caution
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Alimpenam C 500mg/500mg Injection 1’s Alembic Pharma Europa Healthcare
Bacqure 500mg/500mg Injection 1’s Sun Pharma Sun Pharma
Imicil 500mg/500mg Injection 1’s Synermed Pharma Synermed Pharma
Imistin 1g/1g Injection 1’s Zawadi Healthcare Zawadi Healthcare
Imistin 500mg/500mg Injection 1’s Zawadi Healthcare Zawadi Healthcare
Inno-Cila 500mg/500mg Injection 1’s Innocia Lifesciences Wessex Pharma
Lastinem 500mg/500mg Injection 1’s Venus Remedies Surgipharm Ltd
Pelastin 500mg/500mg Injection 1’s PT Sanbe Farma Sai Pharma
Tienam 500mg/500mg Injection 1’s MSD Ltd Imperial Managed