- Bacterial infections:
- Adult: IV 500mg every 6 hours or 1g every 6-8 hours
- Max 4g/day
- Intra-abdominal infections:
- Adult: IV 500mg every 6 hours or 1g every 6-8 hours
- Max 4g/day
- Uncomplicated UTI:
- IV 500mg every 6 hours
- Hospital-acquired or community-acquired pneumonia:
- IV 500mg every 6 hours *1/52
- IV 500mg every 6 hours *1/52
- Chemotherapy-induced febrile neutropenia (Off-label):
- IV 500mg every 6 hours
- Max 4g/day
- Systemic anthrax:
- IV 1g every 6 hours for at least 2 weeks
- Max 4g/day
- Not 1st-line agent
- Part of multi-drug regimen
- Switch to oral antibiotics for post-exposure prophylaxis if inhalational exposure
Injection: 500mg/500mg
- Do not administer by IV push
- If nausea or vomiting occurs during administration, reduce infusion rate
Imipenem: carbapenem; it binds to peptidoglycan, inhibiting cell wall synthesis
Cilastatin: Beta-lactam; inhibits renal dihydropeptidase I, preventing imipenem metabolism
- Increased eosinophils
- Increased LFTs
- Seizures (peds patients)
- Increased Cr
- Platelet abnormalities
- Diarrhea
- Thrombophlebitis
- Oliguria (peds patients)
- Anuria (peds patients)
- Rash
- Nausea
- Hypersensitivity to components/class
None restricted
Drug Status
Availability | Prescription only |
Pregnancy | Category B3 |
Breastfeeding | Use with caution |
Schedule | Not controlled |
BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
---|---|---|---|---|---|
Alimpenam C | 500mg/500mg | Injection | 1’s | Alembic Pharma | Europa Healthcare |
Bacqure | 500mg/500mg | Injection | 1’s | Sun Pharma | Sun Pharma |
Imicil | 500mg/500mg | Injection | 1’s | Synermed Pharma | Synermed Pharma |
Imistin | 1g/1g | Injection | 1’s | Zawadi Healthcare | Zawadi Healthcare |
Imistin | 500mg/500mg | Injection | 1’s | Zawadi Healthcare | Zawadi Healthcare |
Inno-Cila | 500mg/500mg | Injection | 1’s | Innocia Lifesciences | Wessex Pharma |
Lastinem | 500mg/500mg | Injection | 1’s | Venus Remedies | Surgipharm Ltd |
Pelastin | 500mg/500mg | Injection | 1’s | PT Sanbe Farma | Sai Pharma |
Tienam | 500mg/500mg | Injection | 1’s | MSD Ltd | Imperial Managed |