• Susceptible bacterial infections:
    • Conventional interval dosing: IV/IM 3-5 mg/kg/day IV/IM divided TDS
    • Extended interval dosing: IV 5-7 mg/kg/dose OD
      • Not indicated in pregnancy, burns, ascites, obesity, neutropenia or endocarditis
    • Infants: IV/IM 2.5mg/kg/dose TDS
    • Children and adolescents: IV/IM 2-2.5mg/kg/dose TDS
  • Gram-positive bacterial endocarditis:
    • IV 3mg/kg/dose OD for at least *2/52
    • Used in combination with other antibacterials
  • Uncomplicated gonococcal infections (infections of cervix, urethra, rectum):
    • IM 240mg *1
    • Given with azithromycin
    • Not 1st line
  • Severe PID:
    • IM/IV 3-5mg/kg/dose OD *14/7 OR IM/IV 2mg/kg/dose*1, then 1.5mg/kg/dose TDS *14/7
    • Given with clindamycin
    • Not 1st line agent
  • Hospital-acquired pneumonia:
    • IV 5-7mg/kg/dose OD *1/52
    • May extend dose based on clinical response
  • UTI (pyelonephritis):
    • IV 5-7mg/kg/dose IV *1
    • To complete treatment, give ciprofloxacin, levofloxacin or sulfamethoxazole/trimethoprim
  • Surgical prophylaxis:
    • IV 5mg/kg *1 60min prior to surgical incision
    • IV 1.5 mg/kg *1 for gynecology procedures
  • Brucellosis (Off-label):
    • IM/IV 5mg/kg/dose OD *7-10 days
  • Injection/infusion:
    • 10mg/mL
    • 40mg/mL
    • 80mg/mL
  • Infuse over 30 min-2 hours
  • After infusion, flush line with NS or D5W

Aminoglycoside

It binds to bacterial 30S ribosomal subunit thereby inhibiting protein synthesis

  • Dizziness
  • Vertigo
  • Tinnitus
  • Hearing loss
  • Injection site reaction
  • Nephrotoxicity
  • Hypersensitivity to class/components

WARNING:

  • Risk of neurotoxicity/ototoxicity with renal impairment, high-dose and prolonged treatment with ototoxicity usually irreversible. Avoid concurrent and/or sequential neurotoxic agents and potent diuretics
  • Risk of nephrotoxicity with renal impairment, high-dose and prolonged treatment. Avoid concurrent and/or sequential nephrotoxic agents and potent diuretics
  • Risk of neuromuscular blockade including respiratory paralysis
  • Cidofovir

                          Drug Status

Availability Prescription only
Pregnancy Category D
Breastfeeding Enters breast milk; use with caution
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Caregenta 80mg/2mL Injection 10’s Careplus Ltd Careplus Ltd
Genacyn 20mg/2mL Injection 10’s, 25’s Square Pharma Ace Pharma
Genacyn 80mg/2mL Injection 10’s, 25’s Square Pharma Ace Pharma
Gentamycin Fresenius Soution 20mg/2mL Injection 10’s Fresenius Kabi Surgipharm Ltd
Gentax 80mg/2mL Injection 10’s Crown Healthcare Crown Healthcare
Intamycin 80mg/2mL Injection 10’s Radiance Pharma Radiance Pharma
Mycin 80mg/2mL Injection 10’s M/S.Neon Labs Ripple Pharma
Redgenta 80mg/2mL Injection 10’s Reddys Pharma Reddys Pharma
Zenagent 80mg/2mL Injection 10’s Laborate India Harley’s Ltd