• Group A streptococcal infections:
    • Adults: IM 0.6-2 million units/day divided OD/BD *10-14 days
    • <2kg: IM 50,000 units/kg/dose OD
    • 2-27kg: IM 300,000 units OD *10-14 days OR IM 25,000-50,000 units/kg/day divided OD/BD
  • Neurosyphilis:
    • IM 2.4 million units OD *10-14 days
  • Congenital syphilis:
    • IM 50,000 units/kg/dose OD *10/7
  • Fusobacterium infections:
    • Adults: IM 0.6-1 million units OD
    • <12 years: IM 25,000-50,000 units/kg/day divided OD/BD
  • Bacterial endocarditis:
    • IM 0.6-1 million units OD
  • Anthrax:
    • Cutaneous: IM 0.6-1 million units OD
    • Inhalation: IM 1.2 million units BD
  • Adjunct treatment in diphtheria:
    • Adults: IM 0.6-1 million units BD *14/7
    • <12 years: IM 12,500-25,000 units/kg/dose BD *14/7. Max: 600,000 units/dose
  • Uncomplicated pneumococcal infections:
    • Adults: IM 0.6-1 million units OD
    • <27 years: IM 300,000 units OD
  • Injection:
    • 4 million units (MU)
  • Do not inject near artery or nerve (may result in permanent neurologic damage)
  • Neonates, infants, small children: Mid-lateral aspect of thigh preferable
  • Older children and adults: Deep IM injection in upper outer quadrant of buttock
  • Because of high concentration of suspended matter, needle may be blocked if injection is not made at slow, steady rate

Procaine benzylpenicillin is hydrolyzed into penicillin G once it is released from the injection site. It acts through the inhibition of biosynthesis of cell-wall peptidoglycan, rendering the cell wall osmotically unstable.

  • Rash
  • Urticaria
  • Fever
  • Nausea
  • Vomiting
  • Abdominal pain
  • Diarrhea
  • Injection site reaction
  • Sterile abscess
  • Hypersensitivity to drug/components
  • Hypersensitivity to ester anesthetics
  • IV use
  • Neonates
  • Topical lidocaine
  • Topical prilocaine

                                   Drug Status

Availability Prescription only
Pregnancy Can be used
Breastfeeding Can be used
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Penazole 4 MU Injection 1’s Crown Healthcare Crown Healthcare
PPF 4 MU Injection 1’s Medisel Kenya Medisel Kenya