- Multibacillary leprosy:
- PO 100mg and clofazimine 50mg OD *12 months + rifampicin 600mg and clofazimine 300mg once a month
- < 35kg: PO 50mg daily and reduced rifampicin as well
- Paucibacillary leprosy:
- PO 100mg OD and rifampicin 600mg once a month
- Reduced dosages in low weight patients
- Dermatitis herpetiformis:
- PO 50mg OD
- PO 50mg OD
- Treatment of mild to moderate Pneumocystis jirovecii (Pneumocystis carinii) pneumonia (in combination with trimethoprim)
- PO 100 mg once daily
Tablet: 100mg
- May be treated for longer periods if not responsive within the first 6 or 12 months
Sulfone
It competes with para-aminobenzoic acid (PABA), inhibiting folic acid synthesis. It is bactericidal and bacteriostatic against Mycobacterium leprae
- Fever
- Myalgia
- Headache
- Rigors
- Fatigue
- Malaise
- Dizziness
- Nausea
- Arthralgia
- Pancreatitis
- Photosensitivity
- Rash
- Urticaria
- Vomiting
- Abdominal pain
- Anorexia
- Blurred vision
- Tinnitus
- Albuminuria
- Elevated LFTs
- Hypersensitivity to class/components
- Topical lidocaine
- Topical prilocaine
Drug Status
Availability | Prescription only |
Pregnancy | Category C |
Breastfeeding | Contraindicated |
Schedule | Not controlled |
BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
---|---|---|---|---|---|
Dapsone | 100mg | Tablet | 100’s | Biopharma Ltd | Biopharma Ltd |
Dapsone | 100mg | Tablet | 100’s | Cosmos Ltd | Cosmos Ltd |