- URTI
- LRTI
- Skin &soft tissue and bone infections
- Joint infections
- Bacteremia
- P.O. 150-300mg every 6 hours OR 450mg every 6 hours
- Deep IM injection or by IV infusion: 0.6-2.7g daily in 2-4 divided doses;
- Upto 4.8g daily in life-threatening infection
- >1 month old child: 15-40mg/kg daily in 3-4 divided doses
Tablet/Capsule:
- 150mg
- 300mg
Suspension:
- 75mg/5mL
Injection:
- 150mg/mL
- Not more than 1.2g should be infused within 1 hour and not more than 600mg is given in a single IM injection.
- Discontinue immediately and consult a doctor if diarrhea occurs.
- NOT to use in meningitis due to poor penetration of blood brain barrier.
- NOT to be given as bolus; given over 10-60 minutes.
- Prone to increase risk of drug-resistant bacteria if prescribed in the absence of proven or strongly suspected bacterial infection.
Lincosamide.
It suppresses protein synthesis by binding to 50S ribosomal subunits inhibiting bacterial protein synthesis. It is bacteriostatic or bactericidal depending on drug concentration, organism and infection site.
- Abdominal cramps
- Diarrhea
- Pseudomembranous colitis
- Agranulocytosis
- Fungal overgrowth
- Super infections.
- Newborns
- Hypersensitivity to lincosamides and doxorubicin
- Meningitis
- GI disturbances especially colitis
- Pregnancy & lactation.
Concomitant administration with:
- Erythromycin
- Aminophylline
- Ampicillin
- Barbiturates
- Solutions containing vitamin B complex
- Phenytoin sodium
- Magnesium sulphate
- Calcium gluconate.
Drug Status
| Availability | Prescription or OTC by pharmacist |
| Pregnancy | Category B; Contraindicated |
| Breastfeeding | Contraindicated |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Bergclin | 300mg | Tablet | 10’S | Chebu Pharma | Synermed Pharma |
| Calidin | 300mg | Injection | 5’s | Incepta Pharma | Radiance Pharma |
| Clindamycin Fresenius | 600mg/4mL | Injection | 10’s | Fresenius Kabi | Surgipharm Ltd |
| Clindar B | 150mg | Tablet | 100’S | Wallace Pharma | Globe Pharmacy |
| Clindar Injection | 150mg/mL | Injection | 2’s | Wallace Pharma | Globe Pharmacy |
| Clindazed | 300mg | Capsule | 10’s | Zawadi Healthcare | Zawadi Healthcare |
| Dacillin | 150mg | Capsule | 10’s | Innocia Lifesciences | Wessex Pharma |
| Dacillin | 300mg | Capsule | 10’s | Innocia Lifesciences | Wessex Pharma |
| Dalacin | 75mg/5mL | Suspension | 1’s | Pfizer Labs | Pfizer Labs |
| Dalacin C | 150mg | Capsule | 16’s | Pfizer Labs | Pfizer Labs |
| Dalacin C | 300mg | Capsule | 16’s | Pfizer Labs | Pfizer Labs |
| Dalacin C | 600mg/4mL | Injection | 1’s | Pfizer Labs | Pfizer Labs |
| Dalacin C | 300mg/2mL | Injection | 1’s | Pfizer Labs | Pfizer Labs |
| Dalacin C | 1% w/v | Lotion | 30mL | Pfizer Labs | Pfizer Labs |