- Bacterial infections:
- PO 500mg BD or 750mg BD in severe infections
- IV 400mg BD/TDS given over 60 minutes
- UTI:
- Uncomplicated pyelonephritis: PO 500mg BD *1/52
- Complicated: PO 500mg BD *7-14 days OR IV 400mg BD *7-14 days given over 60 minutes
- Only used if other options not available
- Complicated intra-abdominal infections:
- PO 500mg BD OR IV 400mg BD * 7-14 days
- PO 500mg BD OR IV 400mg BD * 7-14 days
- Bone & joint infections:
- Mild-moderate: PO 500mg BD OR IV 400mg BD *≥4-6 weeks
- Severe-complicated: PO 750mg BD OR IV 400mg BD * ≥4-6 weeks
- Chronic bacterial prostatis:
- Mild/moderate: PO 500mg BD OR IV 400mg BD 28/7
- Mild/moderate: PO 500mg BD OR IV 400mg BD 28/7
- Hospital-acquired or community-acquired pneumonia:
- IV 400mg TDS *1/52
- IV 400mg TDS *1/52
- Anthrax:
- Inhalation anthrax (prophylaxis/post-exposure): PO 500mg BD OR IV 400mg BD *2/12
- Cutaneous: PO 500mg BD OR IV 400mg BD *2/12
- First-line agent
- Gonorrhea:
- PO 500mg *1
- PO 500mg *1
- Empirical therapy in febrile neutropenic patients
- Severe: IV 400mg TDS *7-14 days
- Severe: IV 400mg TDS *7-14 days
- Prevention of secondary case of meningococcal meningitis:
- Child 1 month-4 years: PO 30mg/kg (max. per dose 125 mg) *1
- Child 5-11 years: PO 250mg *1
- >12 years: PO 500mg *1
- Surgical prophylaxis:
- PO 750mg taken 60 minutes before procedure
- Tablets:
- 250mg
- 500mg
- 750mg
- Injection:
- 2mg/2mL
- Reserve fluoroquinolones for patients who do not have other available treatment options for uncomplicated UTIs.
- Avoid excess exposure to sunlight.
- Not to be taken with products containing calcium, magnesium, zinc, antacids or aluminum.
- Used in caution in children with history of epilepsy or conditions that predispose to seizures, in G6PD deficiency, mysthaenia gravis.
- Infuse into large vein over 60 min
Fluoroquinolone
It inhibits DNA gyrase in susceptible organisms; promotes breakage of double-stranded DNA.
- Nausea & vomiting
- Diarrhea
- Abdominal pain
- Headache
- Dyspepsia
- Dizziness
- Restlessness
- Lightheadedness
- Vaginitis
- Insomnia
- Photosensitivity
- Pruritus
- Rash
- Anxiety
- Agitation
- Confusion
- Tendinitis
- Arthralgia
- Elevated LFTs
- Myalgia
- Disorientation
- Attention disturbance
- Nervousness
- Impaired memory
- Delirium
- Paranoia
- Hallucinations
- Nightmares
- Tremor
- Hyperglycemia
- Hypersensitivity to drug/class/components
- Patients >60 years
- Myasthenia gravis
- Aortic aneurysm risk or history
- Marfan syndrome
- Ehlers-Danlos syndrome
- Avoid breastfeeding 3-4 hours after anthrax dose use
- Avoid breastfeeding during treatment and for 2 days after discontinuation (non-anthrax use)
- Cisapride
- Eliglustat
- Flibanserin
- Lomitapide
- Lonafarnib
- Pimozide
- Thioridazine
- Tizanidine
- Theophylline
- Metoclopramide increases absorption
- Antacids decrease absorption.
- Probenecid increases serum concentration.
- Fenbufen increases CNS side effects.
Drug Status
| Availability | Prescription only |
| Pregnancy | Category C |
| Breastfeeding | Contraindicated |
| Schedule | Not controlled |
| BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
|---|---|---|---|---|---|
| Axacip | 200mg/100mL | Injection | 1’s | Axa Parenterals | Axa Parenterals |
| Bactiflox | 500mg | Tablet | 10’s | Acino Pharma | Goodman Agencies |
| Bruflox | 500mg | Tablet | 100’s | National Pharmacy | National Pharmacy |
| Ciflox | 500mg | Tablet | 10’s, 100’s | Biopharma Ltd | Biopharma Ltd |
| C-Cipro | 500mg | Tablet | 100’s | Crown Healthcare | Crown Healthcare |
| Ceepro | 500mg | Tablet | 10’s | Lincoln Pharma C/O Medox Pharma | Medox Pharma |
| Cifin | 200mg/100mL | Injection | 1’s | Abacus Pharma | Abacus Pharma |
| Ciflo | 500mg | Tablet | 100’s | Elys Chemicals | Elys Chemicals |
| Cifran | 200mg/100mL | Injection | 1’s | Sun Pharma | Sun Pharma |
| Cifran | 500mg | Tablet | 20’s | Sun Pharma | Sun Pharma |
| Ciproglax | 500mg | Tablet | 100’s | Pharma Life Science | Pharma Life Science |
| Cip-Life | 2mg/mL | Injection | 100mL | Zawadi Healthcare | Zawadi Healthcare |
| Cipcina | 500mg | Tablet | 100’s | Careplus Ltd | Careplus Ltd |
| Cipex | 500mg | Tablet | 100’s | Medico Remedies | Harley’s Ltd |
| Ciprind | 500mg | Tablet | 100’s | Indoco Remedies | Sai Pharma |
| Cipro-Denk | 500 mg | Tablet | 10’s | Denk Pharma | Laborex Kenya |
| Cipro-Denk | 750 mg | Tablet | 10’s | Denk Pharma | Laborex Kenya |
| Ciprobay | 250mg | Tablet | 10’s | Bayer Schering | Bayer Schering |
| Ciprobay | 500mg | Tablet | 10’s | Bayer Schering | Bayer Schering |
| Ciprobay | 750mg | Tablet | 10’s | Bayer Schering | Bayer Schering |
| Ciprobay IV | 200mg | Injection | 100mL | Bayer Schering | Bayer Schering |
| Ciprobay IV | 400mg | Injection | 200mL | Bayer Schering | Bayer Schering |
| Ciprobay XR | 1g | Tablet | 7’s | Bayer Schering | Bayer Schering |
| Ciprobay XR | 500mg | Tablet | 3’s | Bayer Schering | Bayer Schering |
| Ciprobiotic | 500mg | Tablet | 100’s | Emcure Pharma | Lazor Pharma |
| Ciprocor | 500mg | Tablet | 10’s | Signature Healthcare | Signature Healthcare |
| Ciprocor | 1g | Tablet | 10’s | Signature Healthcare | Signature Healthcare |
| Ciprocos | 250mg | Tablet | 100’s | Cosmos Ltd | Cosmos Ltd |
| Ciprocos | 500mg | Tablet | 100’s | Cosmos Ltd | Cosmos Ltd |
| Ciprodac | 500mg | Tablet | 100’s | Cadila Pharm | Cadila Pharm |
| Ciprodeal | 500mg | Tablet | 100’s | Biodeal Labs | Biodeal Labs |
| Ciprofloxacin IV | 2mg/mL | Injection | 100mL | Dawa Ltd | Dawa Ltd |
| Ciprofred | 500mg | Tablet | 10’s | Crown Healthcare | Crown Healthcare |
| Ciprointa | 500mg | Tablet | 10’s | Intas Pharma | Accord Healthcare |
| Ciproken | 500mg | Tablet | 20’s | Square Pharma | Ace Pharma |
| Ciprokant | 500mg | Tablet | 100’s | S Kant Healthcare | S Kant Healthcare |
| Ciprolab | 500mg | Tablet | 100’s | Laboratory & Allied | Laboratory & Allied |
| Ciprolab | 250mg | Tablet | 100’s | Laboratory & Allied | Laboratory & Allied |
| Ciproleb | 500mg | Tablet | 100’s | Leben Labs | Unisel Ltd |
| Cipronat | 500mg | Tablet | 14’s | Dafra Pharm | Energia Pharm |
| Cipronat | 750mg | Tablet | 14’s | Dafra Pharm | Energia Pharm |
| Ciproquin | 250mg | Tablet | 100’s | Kopran Limited | Surgilinks Ltd |
| Ciproquin | 500mg | Tablet | 100’s | Kopran Limited | Surgilinks Ltd |
| Ciproriv | 500mg | Tablet | 10’s | Riva Pharma | Salama Pharma |
| Ciprost | 500mg | Tablet | 10’s | Sterling Lab | Pharma Specialities |
| Ciprox | 200mg/100mL | Injection | 1’s | Claris Otsuka | Reddys Pharma |
| Ciprozed | 500mg | Tablet | 100’s | Zest Pharma | Synermed Pharma |
| Galcipro | 500mg | Tablet | 100’s | Galpha Labs | Medilife Biologicals |
| Kuin | 500mg | Tablet | 10’s | Pharmaken Ltd | Pharmaken Ltd |
| Ladinin | 250mg | Tablet | 10’s | Pharmathen Pharma | Goodman Agencies |
| Ladinin | 500mg | Tablet | 10’s | Pharmathen Pharma | Goodman Agencies |
| Ladinin | 200mg/100mL | Injection | 1’s | Pharmathen Pharma | Goodman Agencies |
| Neocip | 500mg | Tablet | 10’s | Dinlas Pharma | Dinlas Pharma |
| Neofloxin | 500mg | Tablet | 50’s | Beximco Pharma | Madawa Pharma |
| Nircip | 200mg/100mL | Injection | 1’s | Aculife Healthcare | Crown Healthcare |
| Omacip | 500mg | Tablet | 10’s | National Pharma | Nairobi Enterprises |
| Servilox | 500mg | Tablet | 14’s | Sandoz GMBH | Novartis Kenya |
| Shalcip | 500mg | Tablet | 10’s | Shalina Labs | Shalina Healthcare |
| Ultraflox | 500mg | Tablet | 10’s | Orange Pharma | Orange Pharma |
| Viprolox | 500mg | Tablet | 10’s | Delorbis Pharma | Europa Healthcare |
| Winbac | 500mg | Tablet | 10’s | Radiant Pharma | Radiant Pharma |