• Life-threatening bacterial infections untreatable with less toxic antimicrobials:
    • Adults:
      • IV 50-100mg/kg/day divided QID
      • Max 100 mg/kg/day
      • PO 50mg/kg/day divided QID
    • Premature neonates <1.2kg:
      • IV 20-22mg/kg/dose OD *1
      • Give 1st maintenance dose 12h after start dose
    • Neonates 0-7 days old or <2kg:
      • IV 50mg/kg/day divided BD
      • Start with 20mg/kg/dose *1
    • Infants/children:
      • IV 50-75 mg/kg/day divided QID
      • Max: 4g/day
      • PO 12.5mg/kg QID
  • Bacterial meningitis:
    • IV 4g/day divided QID OR IV 75-100 mg/kg/day divided QID
      • IV 6g/day divided QID if pneumococcal
      • Max 100 mg/kg/day
    • PO 50mg/kg/day divided QID
  • Systemic anthrax (Off-label):
    • IV 1g TDS/QID *2/52
  • Injection:
    • 1g
  • Capsule:
    • 250mg
  • Suspension:
    • 125mg/5mL
  • Not first-line agent
  • Infuse via direct IV over 3-5 min; intermittent infusion over 30-60 min

It binds to 50S ribosomal subunit, inhibiting protein synthesis

  • Headache
  • Nausea
  • Vomiting
  • Diarrhea
  • Fever
  • Rash
  • Urticaria
  • Pruritus
  • Peripheral neuropathy
  • Optic neuritis
  • Blurred vision
  • Hypersensitivity to drug or ingredient
  • Pregnancy
  • Breastfeeding
  • Infants
  • Mild infection

WARNING

Serious and fatal blood dyscrasias, including aplastic anemia, hypoplastic anemia, thrombocytopenia and granulocytopenia, have occurred after short-term and prolonged therapy

  • Alfuzosin
  • Alprazolam
  • Cisapride
  • Colchicine
  • Conivaptan
  • Dihydroergotamine
  • Dronedarone
  • Eliglustat
  • Eplerenone
  • Ergotamine
  • Finerenone
  • Flibanserin
  • Isavuconazonium
  • Ivabradine
  • Lomitapide
  • Lonafarnib
  • Lovastatin
  • Lurasidone
  • Mavacamten
  • Naloxegol
  • Pacritinib
  • Pimozide
  • Ranolazine
  • Silodosin
  • Simvastatin
  • Tolvaptan
  • Ubrogepant
  • Venetoclax
  • Voclosporin

                                   Drug Status

Availability Prescription only
Pregnancy Contraindicated
Breastfeeding Contraindicated
Schedule Not controlled
BRAND NAME STRENGTH FORMULATION PACK SIZE MANUFACTURER DISTRIBUTOR
Biophenicol 250mg Capsule 100’s, 1000’s Biodeal Labs Biodeal Labs
Biophenicol 125mg/5mL Suspension 60mL, 100mL Biodeal Labs Biodeal Labs
Careclorfen 1g Injection 10’s Careplus Ltd Careplus Ltd
Chlorocide 125mg/5mL Suspension 100mL Regal Pharma Regal Pharma
Dawaphenicol 125mg/5mL Suspension 60mL, 100mL Dawa Ltd Dawa Ltd
Euchlor 1g Injection 1g Umedica Labs Unisel Ltd
Mediphenicol 125mg/5mL Suspension 60mL, 100mL Medivet Products Medivet Products
Mediphenicol 1g Injection 1’s Medisel Kenya Medisel Kenya
Oramnicol 250mg Capsule 100’s Laboratory & Allied Laboratory & Allied
Tyde-S 1g Injection 1’s M/S.Neon Labs Ripple Pharma