- Life-threatening bacterial infections untreatable with less toxic antimicrobials:
- Adults:
- IV 50-100mg/kg/day divided QID
- Max 100 mg/kg/day
- Adults:
-
-
- PO 50mg/kg/day divided QID
- PO 50mg/kg/day divided QID
-
-
- Premature neonates <1.2kg:
- IV 20-22mg/kg/dose OD *1
- Give 1st maintenance dose 12h after start dose
- Premature neonates <1.2kg:
-
- Neonates 0-7 days old or <2kg:
- IV 50mg/kg/day divided BD
- Start with 20mg/kg/dose *1
- Neonates 0-7 days old or <2kg:
-
- Infants/children:
- IV 50-75 mg/kg/day divided QID
- Max: 4g/day
- Infants/children:
-
-
- PO 12.5mg/kg QID
- PO 12.5mg/kg QID
-
- Bacterial meningitis:
- IV 4g/day divided QID OR IV 75-100 mg/kg/day divided QID
- IV 6g/day divided QID if pneumococcal
- Max 100 mg/kg/day
- PO 50mg/kg/day divided QID
- IV 4g/day divided QID OR IV 75-100 mg/kg/day divided QID
- Systemic anthrax (Off-label):
- IV 1g TDS/QID *2/52
- Injection:
- 1g
- Capsule:
- 250mg
- Suspension:
- 125mg/5mL
- Not first-line agent
- Infuse via direct IV over 3-5 min; intermittent infusion over 30-60 min
It binds to 50S ribosomal subunit, inhibiting protein synthesis
- Headache
- Nausea
- Vomiting
- Diarrhea
- Fever
- Rash
- Urticaria
- Pruritus
- Peripheral neuropathy
- Optic neuritis
- Blurred vision
- Hypersensitivity to drug or ingredient
- Pregnancy
- Breastfeeding
- Infants
- Mild infection
WARNING
Serious and fatal blood dyscrasias, including aplastic anemia, hypoplastic anemia, thrombocytopenia and granulocytopenia, have occurred after short-term and prolonged therapy
- Alfuzosin
- Alprazolam
- Cisapride
- Colchicine
- Conivaptan
- Dihydroergotamine
- Dronedarone
- Eliglustat
- Eplerenone
- Ergotamine
- Finerenone
- Flibanserin
- Isavuconazonium
- Ivabradine
- Lomitapide
- Lonafarnib
- Lovastatin
- Lurasidone
- Mavacamten
- Naloxegol
- Pacritinib
- Pimozide
- Ranolazine
- Silodosin
- Simvastatin
- Tolvaptan
- Ubrogepant
- Venetoclax
- Voclosporin
Drug Status
Availability | Prescription only |
Pregnancy | Contraindicated |
Breastfeeding | Contraindicated |
Schedule | Not controlled |
BRAND NAME | STRENGTH | FORMULATION | PACK SIZE | MANUFACTURER | DISTRIBUTOR |
---|---|---|---|---|---|
Biophenicol | 250mg | Capsule | 100’s, 1000’s | Biodeal Labs | Biodeal Labs |
Biophenicol | 125mg/5mL | Suspension | 60mL, 100mL | Biodeal Labs | Biodeal Labs |
Careclorfen | 1g | Injection | 10’s | Careplus Ltd | Careplus Ltd |
Chlorocide | 125mg/5mL | Suspension | 100mL | Regal Pharma | Regal Pharma |
Dawaphenicol | 125mg/5mL | Suspension | 60mL, 100mL | Dawa Ltd | Dawa Ltd |
Euchlor | 1g | Injection | 1g | Umedica Labs | Unisel Ltd |
Mediphenicol | 125mg/5mL | Suspension | 60mL, 100mL | Medivet Products | Medivet Products |
Mediphenicol | 1g | Injection | 1’s | Medisel Kenya | Medisel Kenya |
Oramnicol | 250mg | Capsule | 100’s | Laboratory & Allied | Laboratory & Allied |
Tyde-S | 1g | Injection | 1’s | M/S.Neon Labs | Ripple Pharma |